[The influence of combined supplementation of glutamine and recombinant human growth hormone on the protein metabolism in severely burned patients]

[The influence of combined supplementation of glutamine and recombinant human growth hormone on the protein metabolism in severely burned patients] Research Abstract Details 

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[The influence of combined supplementation of glutamine and recombinant human growth hormone on the protein metabolism in severely burned patients] Abstract Text:

Cai-jiao Lu,Cai Lin,Jian-jun Xu,Peng Zhang,Guo-zhou Cao,Bao-shun Hong,

OBJECTIVE: To investigate the influence of combined supplementation of glutamine (Gln) and recombinant human growth hormone (rhGH) on the protein metabolism in severely burned patients. METHODS: Sixty severely burned patients were enrolled in the study and were randomly divided into control (C, n = 20) and Gln with rhGH (Gln + rhGH, n = 20) groups. The patients in C group received glycin as the placebo, while those in Gln group took Gln orally in dose of 0.5 g kg(-1) d(-1) during 1-14 postburn days (PBDs). For the patients in Gln + rhGH group rhGH was administered subcutaneously in dose of 0.2 U kg(-1) d(-1) in addition to glutamine in same dosage beginning on the 7 PBD for 7 days. The plasma Gln concentration in the 3 groups of patients was determined on the 1st, 7th and 14th PBD and the plasma albumin level was determined on 14th and 21st PBD. The wound healing rate of the patients within 30 PBSs and the total hospital stay days were recorded. RESULTS: The plasma Gln concentration in Gln + rhGH group of patients was evidently higher than that in C group after 7 PBD[(452.28 +/- 21.72) micromol/L vs(325.12 +/- 25.34) micromol/L, P < 0.05]. The plasma albumin level in Gln + rhGH group was obviously higher than that in C and Gln groups on the 21st PBD (P < 0.05). The wound healing rate in Gln + rhGH group was evidently higher than that in Gln and C groups on the 30th PBD (P < 0.05). The total hospital stay days in Gln + rhGH group were obviously less than that in C and Gln groups (P < 0.05 or 0.01). CONCLUSION: Combined administration of Gln and rhGH could be beneficial to the elevation of plasma Gln level in severely burned patients and the systemic protein synthesis was therefore enhanced and the wound healing rate was improved.

[The influence of combined supplementation of glutamine and recombinant human growth hormone on the protein metabolism in severely burned patients] Publishing Authors By Initials

CJ Lu,C Lin,JJ Xu,P Zhang,GZ Cao,BS Hong,

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[The influence of combined supplementation of glutamine and recombinant human growth hormone on the protein metabolism in severely burned patients] Journal Published:

PUBLICATION TYPE: Randomized Controlled Trial

Journal: Zhonghua shao shang za zhi = Zhonghua shaoshang za

VOLUME: 20

Page Numbers: 220-2

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ISSN: 1009-2587

DAY: 27

MONTH: Aug

YEAR: 2004

[The influence of combined supplementation of glutamine and recombinant human growth hormone on the protein metabolism in severely burned patients] Information

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LANGUAGE: chi

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Grant and Affiliation Information for [The influence of combined supplementation of glutamine and recombinant human growth hormone on the protein metabolism in severely burned patients]

AFFILIATION: Department of Burns, The First Affiliated Hospital of Wenzhou Medical College, Wen Zhou 325014, PR China.

Country: China

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MEDLINETA: Zhonghua Shao Shang Za Zhi

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