The infection of human primary cells and cell lines by human cytomegalovirus: New tropism and new reservoirs for HCMV.

The infection of human primary cells and cell lines by human cytomegalovirus: New tropism and new reservoirs for HCMV. Research Abstract Details 

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The infection of human primary cells and cell lines by human cytomegalovirus: New tropism and new reservoirs for HCMV. Abstract Text:

Wei Wang,Ping Yu,Peng Zhang,Yujun Shi,Hong Bu,Li Zhang,Wei Wang,Ping Yu,Peng Zhang,Yujun Shi,Hong Bu,Li Zhang,

Human cytomegalovirus (HCMV) infection is asymptomatic in common persons and could reactive in immunosuppression groups. HCMV was considered as endothelial cells (EC) tropism and leukocyte tropism. We hypothesized that HCMV will infect other cell types from human which have not been reported yet. The HCMV released from human MRC-5 was inoculated into eight human primary cells and cell lines, including human dermal fibroblasts (HDF), human embryo-chondrocytes (HEC), human embryo-myoblasts (HEM), and human embryo-kidney endothelial cell (HEK-EC), human marrow stromal cell (HMSC). The cell lines were ECV304, Chung liver cell and L02. Several detection methods specific for HCMV, in which PCR for HCMV DNA sequences, immunofluorescence for pp65 antigen, Western-blot for gB protein, as well as cytopathic effect observation were conducted at different time post-infection. The results indicated that four cells in our experiment (HDF, HEM, HEC and HMSC) were HCMV-positive. The occurring time of cytopathic effect was different in these four cells. Our experiment found the new tropism and new reservoirs for HCMV.

The infection of human primary cells and cell lines by human cytomegalovirus: New tropism and new reservoirs for HCMV. Publishing Authors By Initials

W Wang,P Yu,P Zhang,Y Shi,H Bu,L Zhang,W Wang,P Yu,P Zhang,Y Shi,H Bu,L Zhang,

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The infection of human primary cells and cell lines by human cytomegalovirus: New tropism and new reservoirs for HCMV. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Virus research

VOLUME: 131

Page Numbers: 160-9

Journal Abbreviation: Virus Res.

ISSN: 0168-1702

DAY: 25

MONTH: 10

YEAR: 2007

The infection of human primary cells and cell lines by human cytomegalovirus: New tropism and new reservoirs for HCMV. Information

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LANGUAGE: eng

NlmUniqueID: 8410979

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Grant and Affiliation Information for The infection of human primary cells and cell lines by human cytomegalovirus: New tropism and new reservoirs for HCMV.

AFFILIATION: Key Laboratory of Transplant Engineering and Immunology, Ministry of Health, West China Hospital, Sichuan University, Chengdu 610041, PR China.

Country: Netherlands

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MEDLINETA: Virus Res

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