The increasing use of silver-based products as antimicrobial agents: a useful development or a cause for concern?

The increasing use of silver-based products as antimicrobial agents: a useful development or a cause for concern? Research Abstract Details 

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The increasing use of silver-based products as antimicrobial agents: a useful development or a cause for concern? Abstract Text:

Roger Bayston,Alison Mills,Steven M Howdle,Waheed Ashraf,

Silver first gained regulatory approval for use as an antimicrobial agent in the early 20th century, but its usage diminished with the introduction of antibiotics in the 1940s. Recently, however, topical silver has gained popularity once again, principally in the management of open wounds. This has been largely due to the spread of methicillin-resistant Staphylococcus aureus and the resultant reduction in first-line antibiotic prescribing. The increase in the use of topical silver has raised issues concerning silver resistance, together with questions about the standardization of antimicrobial testing methods for silver. Issues related to silver product testing include a failure to establish standard procedures for determining MIC values, an absence of recognized breakpoints, a lack of conformity in the way different products release silver and variations in the effects of microbiological media on silver release and the measurement of inhibitory activity. The clinical incidence of silver resistance remains low, and emergence of resistance can be minimized if the level of silver ions released from products is high and the bactericidal activity rapid.

The increasing use of silver-based products as antimicrobial agents: a useful development or a cause for concern? Publishing Authors By Initials

R Bayston,A Mills,SM Howdle,W Ashraf,

For similar inorganic chemicals: silver compounds research abstracts see: inorganic chemicals: silver compounds research

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The increasing use of silver-based products as antimicrobial agents: a useful development or a cause for concern? Journal Published:

PUBLICATION TYPE: Review

Journal: The Journal of antimicrobial chemotherapy

VOLUME: 59

Page Numbers: 587-90

Journal Abbreviation: J. Antimicrob. Chemother.

ISSN: 0305-7453

DAY: 16

MONTH: 02

YEAR: 2007

The increasing use of silver-based products as antimicrobial agents: a useful development or a cause for concern? Information

Number of References: 39

LANGUAGE: eng

NlmUniqueID: 7513617

The increasing use of silver-based products as antimicrobial agents: a useful development or a cause for concern? Keywords Mesh Terms:

KEYWORDS: Silver Compounds

MESH TERMS: pharmacology

Chemical & Substance for Abstract: The increasing use of silver-based products as antimicrobial agents: a useful development or a cause for concern? Information

Substance Name: Silver Compounds

Registry Number: 0

Grant and Affiliation Information for The increasing use of silver-based products as antimicrobial agents: a useful development or a cause for concern?

AFFILIATION: Antimicrobial Research Centre and Institute for Molecular and Cellular Biology, University of Leeds, Leeds LS2 9JT, UK. i.chopra@leeds.ac.uk

Country: England

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MEDLINETA: J Antimicrob Chemother

REFSOURCE: J Antimicrob Chemother. 2007 Aug;60(2):4

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