The incidence of T2-weighted MR imaging signal abnormalities in the brain of cocaine-dependent patients is age-related and region-specific.

The incidence of T2-weighted MR imaging signal abnormalities in the brain of cocaine-dependent patients is age-related and region-specific. Research Abstract Details 

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The incidence of T2-weighted MR imaging signal abnormalities in the brain of cocaine-dependent patients is age-related and region-specific. Abstract Text:

G Bartzokis,I B Goldstein,D B Hance,M Beckson,D Shapiro,P H Lu,N Edwards,J Mintz,P Bridge,

BACKGROUND AND PURPOSE: Cocaine and its metabolites can produce vasospasm, and cocaine-dependent patients are at increased risk for stroke. Based on previous case reports, we hypothesized that the incidence of hyperintense brain lesions observed on T2-weighted MR images would also be increased in asymptomatic cocaine-dependent individuals. METHODS: Sixty-two male "crack" (smoked) cocaine-dependent participants ranging in age from 25 to 66 years were compared with 116 normal male control participants ranging in age from 25 to 80 years. Those with histories of neurologic symptoms or illnesses were excluded. The severity of hyperintense lesions was rated on a 0- to 3-point scale, and ratings of 3 were used in the data analysis as an indicator of a probable pathologic process. Three regions were separately rated: the cerebral white matter, insular subcortex white matter, and subcortical gray matter (basal ganglia and thalamus region). RESULTS: Significantly increased risk of severe lesions was observed in the two white matter regions of the cocaine-dependent group (odds ratio of 16.7 and 20.3) but not in the subcortial gray matter region (odds ratio of 1.4). In the insula subcortex white matter, the risk of lesions increased with age in the cocaine-dependant sample, but remained essentially absent among normal controls through the age of 80 years. In the cerebral white matter, the relationship of age and risk of lesion among normal participants was similar in shape to that in cocaine-dependent participants, but equivalent risk was seen 20 years earlier among cocaine-dependent participants. CONCLUSIONS: Cocaine-dependent participants had a significantly increased age-related risk of white matter damage. The possible clinical implications of this damage are discussed.

The incidence of T2-weighted MR imaging signal abnormalities in the brain of cocaine-dependent patients is age-related and region-specific. Publishing Authors By Initials

G Bartzokis,IB Goldstein,DB Hance,M Beckson,D Shapiro,PH Lu,N Edwards,J Mintz,P Bridge,

For similar nervous system diseases: central nervous system diseases: brain diseases: cerebrovascular disorders: vasospasm, intracranial research abstracts see: nervous system diseases: central nervous system diseases: brain diseases: cerebrovascular disorders: vasospasm, intracranial research

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The incidence of T2-weighted MR imaging signal abnormalities in the brain of cocaine-dependent patients is age-related and region-specific. Journal Published:

PUBLICATION TYPE: Research Support, U.S. Gov't,

Journal: AJNR. American journal of neuroradiology

VOLUME: 20

Page Numbers: 1628-35

Journal Abbreviation:

ISSN: 0195-6108

DAY: 14

MONTH: Oct

YEAR: 1999

The incidence of T2-weighted MR imaging signal abnormalities in the brain of cocaine-dependent patients is age-related and region-specific. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 8003708

The incidence of T2-weighted MR imaging signal abnormalities in the brain of cocaine-dependent patients is age-related and region-specific. Keywords Mesh Terms:

KEYWORDS: Vasospasm, Intracranial

MESH TERMS: diagnosis

Chemical & Substance for Abstract: The incidence of T2-weighted MR imaging signal abnormalities in the brain of cocaine-dependent patients is age-related and region-specific. Information

Substance Name: Crack Cocaine

Registry Number: 0

Grant and Affiliation Information for The incidence of T2-weighted MR imaging signal abnormalities in the brain of cocaine-dependent patients is age-related and region-specific.

AFFILIATION: Mental Health Service Line, Central Arkansas Veterans Healthcare System, Little Rock 72114, USA.

Country: UNITED STATES

AGENCY: United States NIA

GRANT: AG-11595

ACRONYM: AG

MEDLINETA: AJNR Am J Neuroradiol

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