The important role of caspase-10 in sodium butyrate-induced apoptosis.

The important role of caspase-10 in sodium butyrate-induced apoptosis. Research Abstract Details 

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The important role of caspase-10 in sodium butyrate-induced apoptosis. Abstract Text:

Kazunari Nohara,Yoshiko Yokoyama,Kazutaka Kano,

Butyrate, a short chain fatty acid, exhibits a wide variety of biological effects including the inhibition of cell growth, change of cellular morphology and the induction of apoptosis. Sodium butyrate-induced apoptosis has been reported to associate with the up-regulation of pro-apoptotic Bax expression, and the down-regulation of anti-apoptotic Bcl-2 and Bcl-XL expressions. However, in some cases, butyrate has also been shown to cause apoptosis without change in Bcl-2, Bcl-XL and/or Bax. This study investigates the detailed mechanisms of sodium butyrate-induced apoptosis. The effect of sodium butyrate was analyzed in the induction of caspase activities, formation of caspase active forms and mRNA levels in human breast cancer cell line MRK-nu-1. Induction of activities of caspase-3, -10 and, to some extent, -8 and formation of DNA fragmentation were observed with sodium butyrate in a dose- and/or time-dependent manner. The levels of caspase-10 mRNA expression markedly increased in a time-dependent manner by the treatment of sodium butyrate, whereas caspase-8 mRNA expression was not changed. Inhibitors of caspase-8 and caspase-10 reduced caspase-3 activity and subsequent DNA fragmentation induced by sodium butyrate. These caspase inhibitors also inhibited the cleavage of pro-caspase-3 to the active forms indicated by Western blotting analysis. Pyrrolidine dithiocarbamate also inhibited the induction of caspase-10 mRNA expression and caspase-3 activation. Contrary to other reports, levels of Bcl-2, Bcl-XL and Bax mRNA expressions were not distinctly changed by even 5 mM sodium butyrate treatment. Our results suggest that sodium butyrate may trigger apoptosis via the induction of the caspase-10 expression.

The important role of caspase-10 in sodium butyrate-induced apoptosis. Publishing Authors By Initials

K Nohara,Y Yokoyama,K Kano,

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The important role of caspase-10 in sodium butyrate-induced apoptosis. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: The Kobe journal of medical sciences

VOLUME: 53

Page Numbers: 265-73

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ISSN: 0023-2513

DAY: 21

MONTH: 01

YEAR: 2007

The important role of caspase-10 in sodium butyrate-induced apoptosis. Information

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LANGUAGE: eng

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Grant and Affiliation Information for The important role of caspase-10 in sodium butyrate-induced apoptosis.

AFFILIATION: Departments of Molecular Epidemiology, Kobe University Graduate School of Medicine, Kobe, Japan.

Country: Japan

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MEDLINETA: Kobe J Med Sci

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