The importance of HLA-DPB1 in unrelated donor hematopoietic cell transplantation.

The importance of HLA-DPB1 in unrelated donor hematopoietic cell transplantation. Research Abstract Details 

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The importance of HLA-DPB1 in unrelated donor hematopoietic cell transplantation. Abstract Text:

Bronwen E Shaw,Theodore A Gooley,Mari Malkki,J Alejandro Madrigal,Ann B Begovich,Mary M Horowitz,Alois Gratwohl,Olle ,Steven G E Marsh,Effie W Petersdorf,Bronwen E Shaw,Theodore A Gooley,Mari Malkki,J Alejandro Madrigal,Ann B Begovich,Mary M Horowitz,Alois Gratwohl,Olle ,Steven G E Marsh,Effie W Petersdorf,

Hematopoietic cell transplantation (HCT) from an HLA-A, HLA-B, HLA-C, HLA-DRB1, and HLA-DQB1 allele-matched unrelated donor is a well-recognized life-saving treatment modality for patients with hematologic disorders. The morbidity and mortality from clinically significant acute graft-versus-host disease (aGVHD) remains a limitation. The extent to which transplantation outcome may be improved with donor matching for HLA-DP is not well defined. The risks of aGVHD, relapse, and mortality associated with HLA-DPB1 allele mismatching were determined in 5929 patients who received a myeloablative HCT from an HLA-A-, HLA-B-, HLA-C-, HLA-DRB1-, and HLA-DQB1-matched or -mismatched donor. There was a statistically significantly higher risk of both grades 2 to 4 aGVHD (odds ratio [OR] = 1.33; P < .001) and grades 3 to 4 aGVHD (OR = 1.26; P < .001) after HCT from an HLA-DPB1-mismatched donor compared with a matched donor. The increased risk of aGVHD was accompanied by a statistically significantly decrease in disease relapse (hazard ratio [HR] = 0.82; P = .01). HLA-DPB1 functions as a classical transplantation antigen. The increased risk of GVHD associated with HLA-DPB1 mismatching is accompanied by a lower risk of relapse. Knowledge of the DPB1 matching status prior to transplantation will aid in more precise risk stratification for the individual patient.

The importance of HLA-DPB1 in unrelated donor hematopoietic cell transplantation. Publishing Authors By Initials

BE Shaw,TA Gooley,M Malkki,JA Madrigal,AB Begovich,MM Horowitz,A Gratwohl,O ,SG Marsh,EW Petersdorf,BE Shaw,TA Gooley,M Malkki,JA Madrigal,AB Begovich,MM Horowitz,A Gratwohl,O ,SG Marsh,EW Petersdorf,

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The importance of HLA-DPB1 in unrelated donor hematopoietic cell transplantation. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Blood

VOLUME: 110

Page Numbers: 4560-6

Journal Abbreviation: Blood

ISSN: 0006-4971

DAY: 28

MONTH: 08

YEAR: 2007

The importance of HLA-DPB1 in unrelated donor hematopoietic cell transplantation. Information

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LANGUAGE: eng

NlmUniqueID: 7603509

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AFFILIATION: Anthony Nolan Research Institute, London, UK. bshaw@doctors.org.uk

Country: United States

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MEDLINETA: Blood

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