The impact of sex and smoking status on the mutational spectrum of epidermal growth factor receptor gene in non small cell lung cancer.

The impact of sex and smoking status on the mutational spectrum of epidermal growth factor receptor gene in non small cell lung cancer. Research Abstract Details 

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The impact of sex and smoking status on the mutational spectrum of epidermal growth factor receptor gene in non small cell lung cancer. Abstract Text:

Shinichi Toyooka,Keitaro Matsuo,Hisayuki Shigematsu,Takayuki Kosaka,Masaki Tokumo,Yasushi Yatabe,Syuji Ichihara,Michio Inukai,Hiroshi Suehisa,Junichi Soh,Katsuyuki Kiura,Kwun M Fong,Huei Lee,Ignacio I Wistuba,Adi F Gazdar,Tetsuya Mitsudomi,Hiroshi Date,Shinichi Toyooka,Keitaro Matsuo,Hisayuki Shigematsu,Takayuki Kosaka,Masaki Tokumo,Yasushi Yatabe,Syuji Ichihara,Michio Inukai,Hiroshi Suehisa,Junichi Soh,Katsuyuki Kiura,Kwun M Fong,Huei Lee,Ignacio I Wistuba,Adi F Gazdar,Tetsuya Mitsudomi,Hiroshi Date,

PURPOSE: Mutation of epidermal growth factor receptor (EGFR) gene has been reported to be present in non-small cell lung cancer (NSCLC) and significantly associated with female sex and never-smoking status. In this study, we extensively investigated the impact of sex and smoking on the EGFR mutation. EXPERIMENTAL DESIGN: We examined EGFR exons 18 to 21 status in 1,467 NSCLC patients by direct sequencing to study the impact of sex and smoking status on the EGFR mutational spectrum. RESULTS: Among 1,467 patients, 197 mutations were found at exon 19, 176 at exon 21, 21 at exon 18, and 24 at exon 20. To examine the independent effect of sex and smoking, the mutational status of each exon was compared between smokers and never smokers in each sex and between males and females stratified by smoking status. In females, exon 19 (P = 0.001) and exon 21 (P < 0.001) mutations were significantly less frequent in ever smokers compared with never smokers. In males, exon 19 (P < 0.001), exon 21 (P < 0.001), and exon 18 (P = 0.003) mutations were significantly less frequent in ever smokers compared with never smokers. In analysis stratified by smoking, there was no difference in sex among never smokers. However, exon 19 mutations were significantly less frequent in males compared with females among ever smokers (P = 0.003). In addition, the interactive effect of male sex and ever smoking status significantly decreased the frequency of exon 19 mutations (P = 0.047) when female never smoker was set as a reference. CONCLUSION: Both sex and smoking status could influence the EGFR mutational spectrum. Our findings suggest that individual EGFR exons may have differing susceptibilities for mutagenesis.

The impact of sex and smoking status on the mutational spectrum of epidermal growth factor receptor gene in non small cell lung cancer. Publishing Authors By Initials

S Toyooka,K Matsuo,H Shigematsu,T Kosaka,M Tokumo,Y Yatabe,S Ichihara,M Inukai,H Suehisa,J Soh,K Kiura,KM Fong,H Lee,II Wistuba,AF Gazdar,T Mitsudomi,H Date,S Toyooka,K Matsuo,H Shigematsu,T Kosaka,M Tokumo,Y Yatabe,S Ichihara,M Inukai,H Suehisa,J Soh,K Kiura,KM Fong,H Lee,II Wistuba,AF Gazdar,T Mitsudomi,H Date,

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The impact of sex and smoking status on the mutational spectrum of epidermal growth factor receptor gene in non small cell lung cancer. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Clinical cancer research : an official journal of

VOLUME: 13

Page Numbers: 5763-8

Journal Abbreviation: Clin. Cancer Res.

ISSN: 1078-0432

DAY: 1

MONTH: Oct

YEAR: 2007

The impact of sex and smoking status on the mutational spectrum of epidermal growth factor receptor gene in non small cell lung cancer. Information

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LANGUAGE: eng

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AFFILIATION: Department of Cancer and Thoracic Surgery, Okayama University, Okayama, Japan. toyooka@md.okayama-u.ac.jp

Country: United States

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MEDLINETA: Clin Cancer Res

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