The impact of HIV status and type on the clearance of human papillomavirus infection among Senegalese women.

The impact of HIV status and type on the clearance of human papillomavirus infection among Senegalese women. Research Abstract Details 

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The impact of HIV status and type on the clearance of human papillomavirus infection among Senegalese women. Abstract Text:

Ali Rowhani-Rahbar,Stephen E Hawes,Papa Salif Sow,Papa Toure,Qinghua Feng,Ahmadou Dem,Birama Dembele,Cathy W Critchlow,Ibraham N'Doye,Nancy B Kiviat,

BACKGROUND: Persistent infection with human papillomavirus (HPV) is associated with the development and progression of HPV-related disease, including cervical intraepithelial neoplasia (CIN) and invasive cervical cancer. METHODS: We examined the impact of human immunodeficiency virus (HIV) status and type on the clearance of HPV infection among 614 Senegalese women enrolled in a longitudinal study of HPV and CIN. Women were examined every 4 months for HPV DNA. Clearance was defined as 2 consecutive negative HPV DNA test results. RESULTS: Cox proportional hazard regression with time-dependent covariates indicated that HIV-positive women were less likely to clear HPV infection (adjusted hazard ratio [HR], 0.31 [95% confidence interval {CI}, 0.21-0.45]) than HIV-negative women. Among HIV-positive women, those with CD4 cell counts <200 or from 200 to 500 cells/microL showed a 71% (adjusted HR, 0.29 [95% CI, 0.11-0.76]) and 32% (adjusted HR, 0.68 [95% CI, 0.31-1.48]) reduction in the likelihood of HPV clearance, respectively, compared with those with CD4 cell counts >500 cells/microL. HIV-2 infection was associated with an increased likelihood of HPV clearance (adjusted HR, 2.46 [95% CI, 1.17-5.16]), compared with that for HIV-1 infection. CONCLUSIONS: HIV infection reduces the likelihood of HPV clearance. Among HIV-positive women, immunosuppression, as measured by CD4 cell count, reduces the likelihood of HPV clearance, and HIV type appears to be associated with HPV clearance.

The impact of HIV status and type on the clearance of human papillomavirus infection among Senegalese women. Publishing Authors By Initials

A Rowhani-Rahbar,SE Hawes,PS Sow,P Toure,Q Feng,A Dem,B Dembele,CW Critchlow,I N'Doye,NB Kiviat,

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The impact of HIV status and type on the clearance of human papillomavirus infection among Senegalese women. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: The Journal of infectious diseases

VOLUME: 196

Page Numbers: 887-94

Journal Abbreviation: J. Infect. Dis.

ISSN: 0022-1899

DAY: 7

MONTH: 08

YEAR: 2007

The impact of HIV status and type on the clearance of human papillomavirus infection among Senegalese women. Information

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LANGUAGE: eng

NlmUniqueID: 413675

The impact of HIV status and type on the clearance of human papillomavirus infection among Senegalese women. Keywords Mesh Terms:

KEYWORDS: Women

MESH TERMS: immunology

Chemical & Substance for Abstract: The impact of HIV status and type on the clearance of human papillomavirus infection among Senegalese women. Information

Substance Name: DNA, Viral

Registry Number: 0

Grant and Affiliation Information for The impact of HIV status and type on the clearance of human papillomavirus infection among Senegalese women.

AFFILIATION: Department of Epidemiology, School of Public Health and Community Medicine, University of Washington, Seattle, WA 98103, USA.

Country: United States

AGENCY: United States NCI

GRANT: CA97275

ACRONYM: CA

MEDLINETA: J Infect Dis

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