The impact of cirrhosis on CD4+ T cell counts in HIV-seronegative patients.

The impact of cirrhosis on CD4+ T cell counts in HIV-seronegative patients. Research Abstract Details 

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The impact of cirrhosis on CD4+ T cell counts in HIV-seronegative patients. Abstract Text:

BACKGROUND: Studies of the progression liver fibrosis in human immunodeficiency virus (HIV) and hepatitis C virus-coinfected patients suggest that cirrhosis is associated with immunosuppression, as measured by low absolute CD4(+) T cell counts. However, we hypothesized that, in patients with advanced liver disease, low CD4(+) T cell counts may occur secondary to portal hypertension and splenic sequestration, regardless of the presence or absence of HIV infection. METHODS: Sixty HIV-seronegative outpatients with cirrhosis were enrolled during the period 2001-2003 in a prospective, cross-sectional study of the association between liver disease and CD4(+) T cell counts and percentages. Demographic characteristics, liver disease-related characteristics, and laboratory results--including CD4(+) T cell parameters--were collected. RESULTS: A total of 39 patients (65%) had a low CD4(+) T cell count; 26 patients (43%) and 4 patients (7%) had CD4(+) T cell counts <350 and <200 cells/mm(3), respectively. Abnormal CD4(+) T cell counts were associated with splenomegaly (P=.03), thrombocytopenia (P=.002), and leukopenia (P<.001). The percentage of CD4(+) T cells was normal in 95% of patients who had a low absolute CD4(+) T cell count. CD4(+) T cell counts were significantly lower among cirrhotic patients than among 7638 HIV-seronegative historic control subjects without liver disease. CONCLUSIONS: Cirrhosis is associated with low CD4(+) T cell counts in the absence of HIV infection. Discordance between low absolute CD4(+) T cell counts and normal CD4(+) T cell percentages may be attributable to portal hypertension and splenic sequestration. Our findings have significant implications for the use and interpretation of absolute CD4(+) T cell counts in HIV-infected patients with advanced liver disease.

The impact of cirrhosis on CD4+ T cell counts in HIV-seronegative patients. Publishing Authors By Initials

For similar pathological conditions, signs and symptoms: pathological conditions, anatomical: hypertrophy: splenomegaly research abstracts see: pathological conditions, signs and symptoms: pathological conditions, anatomical: hypertrophy: splenomegaly research

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The impact of cirrhosis on CD4+ T cell counts in HIV-seronegative patients. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: Clinical infectious diseases : an official publica

VOLUME: 44

Page Numbers: 431-7

Journal Abbreviation: Clin. Infect. Dis.

ISSN: 1537-6591

DAY: 21

MONTH: 12

YEAR: 2006

The impact of cirrhosis on CD4+ T cell counts in HIV-seronegative patients. Information

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LANGUAGE: eng

NlmUniqueID: 9203213

The impact of cirrhosis on CD4+ T cell counts in HIV-seronegative patients. Keywords Mesh Terms:

KEYWORDS: Splenomegaly

MESH TERMS: blood

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Grant and Affiliation Information for The impact of cirrhosis on CD4+ T cell counts in HIV-seronegative patients.

AFFILIATION: Division of Geographic Medicine and Infectious Diseases, Tufts-New England Medical Center, Jamaica Plain, MA 02130, USA. bmcgovern@tufts-nemc.org

Country: United States

AGENCY: United States NCRR

GRANT: M01-RR00054

ACRONYM: RR

MEDLINETA: Clin Infect Dis

REFSOURCE: Clin Infect Dis. 2007 Feb 1;44(3):438-40

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