The impact of aryl hydrocarbon receptor signaling on matrix metabolism: implications for development and disease.

The impact of aryl hydrocarbon receptor signaling on matrix metabolism: implications for development and disease. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

The impact of aryl hydrocarbon receptor signaling on matrix metabolism: implications for development and disease. Abstract Text:

Jedd M Hillegass,Kyle A Murphy,Caren M Villano,Lori A White,Jedd M Hillegass,Kyle A Murphy,Caren M Villano,Lori A White,

The aryl hydrocarbon receptor (AhR) was identified as the receptor for polycyclic aromatic hydrocarbons and related compounds. However, novel data indicate that the AhR binds a variety of unrelated endogenous and exogenous compounds. Although AhR knockout mice demonstrate that this receptor has a role in normal development and physiology, the function of this receptor is still unclear. Recent evidence suggests that AhR signaling also alters the expression of genes involved in matrix metabolism, specifically the matrix metalloproteinases (MMPs). MMP expression and activity is critical to normal physiological processes that require tissue remodeling, as well as in mediating the progression of a variety of diseases. MMPs not only degrade structural proteins, but are also important mediators of cell signaling near or at the cell membrane through exposure of cryptic sites, release of growth factors, and cleavage of receptors. Therefore, AhR modulation of MMP expression and activity may be critical, not only in pathogenesis, but also in understanding the endogenous function of the AhR. In this review we will examine the data indicating a role for the AhR-signaling pathway in the regulation of matrix remodeling, and discuss potential molecular mechanisms.

The impact of aryl hydrocarbon receptor signaling on matrix metabolism: implications for development and disease. Publishing Authors By Initials

JM Hillegass,KA Murphy,CM Villano,LA White,JM Hillegass,KA Murphy,CM Villano,LA White,

For similar abstracts research abstracts see: abstracts research

PUBMED ID PMID:

MEDLINE DATE:

The impact of aryl hydrocarbon receptor signaling on matrix metabolism: implications for development and disease. Journal Published:

PUBLICATION TYPE: Review

Journal: Biological chemistry

VOLUME: 387

Page Numbers: 1159-73

Journal Abbreviation:

ISSN: 1431-6730

DAY: 15

MONTH: Sep

YEAR: 2006

The impact of aryl hydrocarbon receptor signaling on matrix metabolism: implications for development and disease. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 9700112

The impact of aryl hydrocarbon receptor signaling on matrix metabolism: implications for development and disease. Keywords Mesh Terms:

KEYWORDS:

MESH TERMS:

Chemical & Substance for Abstract: The impact of aryl hydrocarbon receptor signaling on matrix metabolism: implications for development and disease. Information

Substance Name:

Registry Number:

Grant and Affiliation Information for The impact of aryl hydrocarbon receptor signaling on matrix metabolism: implications for development and disease.

AFFILIATION: Department of Biochemistry and Microbiology, Rutgers, The State University of New Jersey, 76 Lipman Dr., New Brunswick, NJ 08901, USA.

Country: Germany

AGENCY:

GRANT:

ACRONYM:

MEDLINETA: Biol Chem

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

The impact of aryl hydrocarbon receptor signaling on matrix metabolism: implications for development and disease Related Publications

• A flexible computational framework for detecting, characterizing, and interpreting statistical patterns of epistasis in genetic studies of human disease susceptibility.
• A voltage-sensor water pore.
• Chronic vague abdominal pain in children.
• Cimetidine use and the risk for prostate cancer: results from the VITAL cohort study.
• Do breast cancer risk factors modify the association between hormone therapy and mammographic breast density? (United States).
• Effects of photoperiod and intermittent lighting on reproduction in pheasant hens.
• Exposure to the metabolic inhibitor sodium azide induces stress protein expression and thermotolerance in the nematode Caenorhabditis elegans.
• Extremity trauma research in the United States army.
• Felbamate is a subunit selective modulator of recombinant gamma-aminobutyric acid type A receptors expressed in Xenopus oocytes.
• Harnessing RNAi for Analyses of Ras Signaling and Transformation.
• In vitro maturation and fertilization of swamp buffalo oocytes and their subsequent development.
• Inability to immunize patients with metastatic melanoma using plasmid DNA encoding the gp100 melanoma-melanocyte antigen.
• Inhibitory control in children with phenylketonuria.
• Kinetic mechanism of myosinV-S1 using a new fluorescent ATP analogue.
• Mammographic breast density, dense area, and breast area differences by phase in the menstrual cycle.
• PGI2 opens potassium channels in retinal pericytes by cyclic AMP-stimulated, cross-activation of PKG.
• Parachutes and prophylaxis: they both work!
• Polyol synthesis through hydrocarbon oxidation: de novo synthesis of L-galactose.
• Post-thawing survival of motile ram sperm after isolation by layering on protein columns.
• Prevalence of Borrelia burgdorferi in small mammals in New York state.
• Prospects for sexing mammalian sperm edited by Rupert P. Amman and George E. Seidel, Jr.; 288 pages; Cloth - $32.50, Paper - $22.50. Available from Colorado Associated University Press, 1338 Grandview Avenue, Box 480, University of Colorado, Boulder, Colo
• Ras-Sensitive IMP Modulation of the Raf/MEK/ERK Cascade Through KSR1.
• Relationship between estrone sulfate in plasma and litter size at farrowing for sows and gilts.
• Spontaneous baroreflex sensitivity in young and older people during voluntary and electrically evoked isometric exercise.
• Tc-99m HMPAO SPECT in the differential diagnosis of the dementias with histopathologic confirmation.
• The impact of aryl hydrocarbon receptor signaling on matrix metabolism: implications for development and disease.
• The pharmacokinetics of intravenous artesunate in adults with severe falciparum malaria.
• The preference of tryptophan for membrane interfaces.
• The reciprocal stability of FOXO1 and IRS2 creates a regulatory circuit that controls insulin signaling.
• Using verbal fluency to detect very mild dementia of the Alzheimer type.