The impact of anesthetics and hyperoxia on cortical spreading depression.

The impact of anesthetics and hyperoxia on cortical spreading depression. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

The impact of anesthetics and hyperoxia on cortical spreading depression. Abstract Text:

Cortical spreading depression (CSD), a transient neuronal and glial depolarization that propagates slowly across the cerebral cortex, is the putative electrophysiological event underlying migraine aura. It negatively impacts tissue injury during stroke, cerebral contusion and intracranial hemorrhage. Susceptibility to CSD has been assessed in several experimental animal models in vivo, such as after topical KCl application or cathodal stimulation. Various combinations of anesthetics and ambient conditions have been used by different laboratories making comparisons problematic and differences in data difficult to reconcile. We systematically studied CSD susceptibility comparing commonly used experimental anesthetics (isoflurane, alpha-chloralose, and urethane) with or without N(2)O or normobaric hyperoxia (100% O(2) inhalation). The frequency of evoked CSDs, and their propagation speed, duration, and amplitude were recorded during 2 h topical KCl (1 M) application. We found that N(2)O reduced CSD frequency when combined with isoflurane or urethane, but not alpha-chloralose; N(2)O also decreased CSD propagation speed and duration. Urethane anesthesia was associated with the highest CSD frequency that was comparable to pentobarbital. Inhalation of 100% O(2) did not alter CSD frequency, propagation speed or duration in combination with any of the anesthetics tested. Our data show anesthetic modulation of CSD susceptibility in an experimental model of human disease, underscoring the importance of proper study design for hypothesis testing as well as for comparing results between studies.

The impact of anesthetics and hyperoxia on cortical spreading depression. Publishing Authors By Initials

For similar abstracts research abstracts see: abstracts research

PUBMED ID PMID:

MEDLINE DATE:

The impact of anesthetics and hyperoxia on cortical spreading depression. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Experimental neurology

VOLUME: 212

Page Numbers: 201-6

Journal Abbreviation: Exp. Neurol.

ISSN: 1090-2430

DAY: 11

MONTH: 04

YEAR: 2008

The impact of anesthetics and hyperoxia on cortical spreading depression. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 370712

The impact of anesthetics and hyperoxia on cortical spreading depression. Keywords Mesh Terms:

KEYWORDS:

MESH TERMS:

Chemical & Substance for Abstract: The impact of anesthetics and hyperoxia on cortical spreading depression. Information

Substance Name:

Registry Number:

Grant and Affiliation Information for The impact of anesthetics and hyperoxia on cortical spreading depression.

AFFILIATION: Stroke and Neurovascular Regulation Laboratory, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129, USA.

Country: United States

AGENCY:

GRANT:

ACRONYM:

MEDLINETA: Exp Neurol

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

The impact of anesthetics and hyperoxia on cortical spreading depression Related Publications

• A randomized, double-blind, placebo-controlled pilot study of simvastatin in aneurysmal subarachnoid hemorrhage.
• Age-dependent cerebrovascular dysfunction in a transgenic mouse model of cerebral amyloid angiopathy.
• Hypoxia and hypotension transform the blood flow response to cortical spreading depression from hyperemia into hypoperfusion in the rat.
• Mild induced hypertension improves blood flow and oxygen metabolism in transient focal cerebral ischemia.
• Normobaric hyperoxia improves cerebral blood flow and oxygenation, and inhibits peri-infarct depolarizations in experimental focal ischaemia.
• The impact of anesthetics and hyperoxia on cortical spreading depression.