The impact of 8-aryl-and 8-heteroaryl-2'-deoxyguanosine derivatives on G-quadruplex formation.

The impact of 8-aryl-and 8-heteroaryl-2'-deoxyguanosine derivatives on G-quadruplex formation. Research Abstract Details 

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The impact of 8-aryl-and 8-heteroaryl-2'-deoxyguanosine derivatives on G-quadruplex formation. Abstract Text:

Vladimir Gubala, ,Gerard Hobley, Rivera,

Guanine and G-rich oligonucleotides are known to self-assemble in the presence of a variety of cations to form higher ordered structures known as Gquadruplexes. We have synthesized a library of 8-aryl/heteroaryl-2'-deoxyguanosine derivatives (8ArGs) that are also able to self-assemble into quadruplex structures. We demonstrate that the properties of such quadruplexes can be modulated by the nature of the groups attached to the guanine base. These supramolecules are potentially useful in the development of self-assembled nanodevices.

The impact of 8-aryl-and 8-heteroaryl-2'-deoxyguanosine derivatives on G-quadruplex formation. Publishing Authors By Initials

V Gubala,Mdel ,G Hobley,JM Rivera,

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The impact of 8-aryl-and 8-heteroaryl-2'-deoxyguanosine derivatives on G-quadruplex formation. Journal Published:

PUBLICATION TYPE: Research Support, U.S. Gov't,

Journal: Nucleic acids symposium series (2004)

VOLUME:

Page Numbers: 39-40

Journal Abbreviation: Nucleic Acids Symp Ser (Oxf)

ISSN: 1746-8272

DAY: 21

MONTH: 11

YEAR: 2007

The impact of 8-aryl-and 8-heteroaryl-2'-deoxyguanosine derivatives on G-quadruplex formation. Information

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LANGUAGE: eng

NlmUniqueID: 101259965

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AFFILIATION: Department of Chemistry, University of Puerto Rico, Río Piedras Campus, PO Box 23346, San Juan, Puerto Rico, 00931, USA.

Country: England

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MEDLINETA: Nucleic Acids Symp Ser (Oxf)

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