The immediate and sustained effects of volume challenge on regional blood flows in pigs.

The immediate and sustained effects of volume challenge on regional blood flows in pigs. Research Abstract Details 

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The immediate and sustained effects of volume challenge on regional blood flows in pigs. Abstract Text:

Syed Z Ali,Hendrik Bracht,Vladimir Krejci,Mario Beck,Michael Stalder,Luzius Hiltebrand,Jukka Takala,Sebastian Brandt,Stephan M Jakob,Syed Z Ali,Hendrik Bracht,Vladimir Krejci,Mario Beck,Michael Stalder,Luzius Hiltebrand,Jukka Takala,Sebastian Brandt,Stephan M Jakob,

BACKGROUND: The postoperative assessment of volume status is not straightforward because of concomitant changes in intravascular volume and vascular tone. Hypovolemia and blood flow redistribution may compromise the perfusion of the intraabdominal organs. We investigated the effects of a volume challenge in different intra- and extraabdominal vascular beds. METHODS: Twelve pigs were studied 6 h after major intraabdominal surgery under general anesthesia when clinically normovolemic. Volume challenges consisted of 200 mL rapidly infused 6% hydroxyethyl starch. Systemic (continuous thermodilution) and regional (ultrasound Doppler) flows in carotid, renal, celiac trunk, hepatic, and superior mesenteric arteries and the portal vein were continuously measured. The acute and sustained effects of the challenge were compared with baseline. RESULTS: Volume challenge produced a sustained increase of 22% +/- 15% in cardiac output (P < 0.001). Blood flow increased by 10% +/- 9% in the renal artery, by 22% +/- 15% in the carotid artery, by 26% +/- 15% in the superior mesenteric artery, and by 31% +/- 20% in the portal vein (all P < 0.001). Blood flow increases in the celiac trunk (8% +/- 13%) and the hepatic artery (7% +/- 19%) were not significant. Increases in regional blood flow occurred early and were sustained. Mean arterial and central venous blood pressures increased early and decreased later (all P < 0.05). CONCLUSIONS: A volume challenge in clinically euvolemic postoperative animals was associated with a sustained increase in blood flow to all vascular beds, although the increase in the celiac trunk and the hepatic artery was very modest and did not reach statistical significance. Whether improved postoperative organ perfusion is accompanied by a lower complication rate should be evaluated in further studies.

The immediate and sustained effects of volume challenge on regional blood flows in pigs. Publishing Authors By Initials

SZ Ali,H Bracht,V Krejci,M Beck,M Stalder,L Hiltebrand,J Takala,S Brandt,SM Jakob,SZ Ali,H Bracht,V Krejci,M Beck,M Stalder,L Hiltebrand,J Takala,S Brandt,SM Jakob,

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The immediate and sustained effects of volume challenge on regional blood flows in pigs. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Anesthesia and analgesia

VOLUME: 106

Page Numbers: 595-600, table of contents

Journal Abbreviation: Anesth. Analg.

ISSN: 1526-7598

DAY: 29

MONTH: Feb

YEAR: 2008

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LANGUAGE: eng

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Grant and Affiliation Information for The immediate and sustained effects of volume challenge on regional blood flows in pigs.

AFFILIATION: Department of Anesthesiology, University Hospital Bern, Inselspital, CH-3010 Bern, Switzerland.

Country: United States

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MEDLINETA: Anesth Analg

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