The human urine mannose 6-phosphate glycoproteome.

The human urine mannose 6-phosphate glycoproteome. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

The human urine mannose 6-phosphate glycoproteome. Abstract Text:

David E Sleat,Haiyan Zheng,Peter Lobel,

Glycoproteins containing the mannose 6-phosphate (Man-6-P) modification represent a class of proteins of considerable biomedical importance. They include over sixty different soluble lysosomal hydrolases and accessory proteins, deficiencies of which result in over forty different known human genetic diseases. In addition, there are patients with lysosomal storage diseases of unknown etiology and lysosomal proteins have been implicated in pathophysiological processes associated with Alzheimer disease, arthritis, and cancer. The aim of this study was to explore urine as a source for the proteomic investigation of lysosomal storage disorders as well as for biomarker studies on the role of Man-6-P containing proteins in other human diseases. To this end, urinary proteins were affinity purified on immobilized Man-6-P receptors, digested with trypsin, and analyzed using nanospray LC/MS/MS. This resulted in identification of 67 proteins, including 48 known lysosomal proteins and 9 proteins that may be lysosomal. The identification of a large proportion of the known set of soluble lysosomal proteins with relatively few contaminants suggests that urine represents a promising substrate for the development of comparative proteomic methods for the investigation of lysosomal disorders and other diseases involving Man-6-P glycoproteins.

The human urine mannose 6-phosphate glycoproteome. Publishing Authors By Initials

DE Sleat,H Zheng,P Lobel,

For similar proteins: proteome research abstracts see: proteins: proteome research

PUBMED ID PMID:

MEDLINE DATE:

The human urine mannose 6-phosphate glycoproteome. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: Biochimica et biophysica acta

VOLUME: 1774

Page Numbers: 368-72

Journal Abbreviation: Biochim. Biophys. Acta

ISSN: 0006-3002

DAY: 20

MONTH: 12

YEAR: 2006

The human urine mannose 6-phosphate glycoproteome. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 217513

The human urine mannose 6-phosphate glycoproteome. Keywords Mesh Terms:

KEYWORDS: Proteome

MESH TERMS: metabolism

Chemical & Substance for Abstract: The human urine mannose 6-phosphate glycoproteome. Information

Substance Name: mannose-6-phosphate

Registry Number: 3672-15-9

Grant and Affiliation Information for The human urine mannose 6-phosphate glycoproteome.

AFFILIATION: Center for Advanced Biotechnology and Medicine, University of Medicine and Dentistry of New Jersey, Piscataway, NJ 08854, USA. sleat@cabm.rutgers.edu

Country: Netherlands

AGENCY: United States NCRR

GRANT: S10RR017992

ACRONYM: RR

MEDLINETA: Biochim Biophys Acta

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

The human urine mannose 6-phosphate glycoproteome Related Publications

• Clinical studies with parenteral vitamin A therapy in deafness; preliminary report.
• Demonstration of lysosomal localization for the mammalian ependymin-related protein using classical approaches combined with a novel density shift method.
• Differential Effects of an Adult Observer's Presence on Sex-Typed Play Behavior: A Comparison Between Gender-Schematic and Gender-Aschematic Preschool Children.
• Dipeptidyl-peptidase I does not functionally compensate for the loss of tripeptidyl-peptidase I in the neurodegenerative disease late-infantile neuronal ceroid lipofuscinosis.
• Do mammalian NPC1 and NPC2 play a role in intestinal cholesterol absorption?
• Early endoscopic realignment for complete traumatic rupture of the posterior urethra--21 patients.
• Enhancement of hybridoma formation, clonability and cell proliferation in a nanoparticle-doped aqueous environment.
• Focal enhancement of cranial nerve V after radiosurgery with the Leksell gamma knife: experience in 15 patients with medically refractory trigeminal neuralgia.
• Identification and validation of mannose 6-phosphate glycoproteins in human plasma reveal a wide range of lysosomal and non-lysosomal proteins.
• Minimally invasive transpedicular vertebrectomy for metastatic disease to the thoracic spine.
• Native human autoantibodies targeting GIPC1 identify differential expression in malignant tumors of the breast and ovary.
• Optical fiber immunosensor for the detection of IgG antibody to Rift Valley fever virus in humans.
• Proteomics analysis of serum from mutant mice reveals lysosomal proteins selectively transported by each of the two mannose 6-phosphate receptors.
• Race and gender matter: A multidimensional approach to conceptualizing and measuring stress in African American women.
• Residual levels of tripeptidyl-peptidase I activity dramatically ameliorate disease in late-infantile neuronal ceroid lipofuscinosis.
• The human urine mannose 6-phosphate glycoproteome.
• The mannose 6-phosphate glycoprotein proteome.
• Types, patterns, and predictors of coping with stress during pregnancy: Examination of the Revised Prenatal Coping Inventory in a diverse sample.
• [Consequences of sexually transmissible diseases for male fertility]
• [Conservative treatment of stage III kidney injuries]
• [Lygal zinc paste, a soft paste capable of being removed by washing.]
• [Not Available.]
• [Not Available.]
• [Synchronous bladder metastasis of a clear-cell adenocarcinoma of the kidney]
• [Ureteral reimplantation on psoas bladder: long-term results]