The histone variant CENP-A and centromere specification.

The histone variant CENP-A and centromere specification. Research Abstract Details 

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The histone variant CENP-A and centromere specification. Abstract Text:

Ben E Black,Emily A Bassett,Ben E Black,Emily A Bassett,

The centromere is the chromosomal locus that guides faithful inheritance. Centromeres are specified epigenetically, and the histone H3 variant CENP-A has emerged as the best candidate to carry the epigenetic centromere mark. Recent advances demonstrate the physical basis for this epigenetic mark whereby CENP-A confers conformational rigidity to the nucleosome it forms with other core histones. This nucleosome is recognized by a multisubunit complex of constitutive centromere proteins, termed the CENP-A(NAC). Evidence from two CENP-A relatives in diverse eukaryotes suggests that the histone complexes they form adopt highly unconventional arrangements on DNA. Centromere identity, itself, is propagated during mitotic exit and early G1, and it relies upon a cis-acting targeting domain within CENP-A and a proposed centromere 'priming' reaction.

The histone variant CENP-A and centromere specification. Publishing Authors By Initials

BE Black,EA Bassett,BE Black,EA Bassett,

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The histone variant CENP-A and centromere specification. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Current opinion in cell biology

VOLUME: 20

Page Numbers: 91-100

Journal Abbreviation: Curr. Opin. Cell Biol.

ISSN: 0955-0674

DAY: 15

MONTH: 01

YEAR: 2008

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LANGUAGE: eng

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Grant and Affiliation Information for The histone variant CENP-A and centromere specification.

AFFILIATION: Department of Biochemistry and Biophysics and Program in Biochemistry and Molecular Biophysics, University of Pennsylvania, Philadelphia, PA 19104, United States.

Country: United States

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MEDLINETA: Curr Opin Cell Biol

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