The histidine triad superfamily of nucleotide-binding proteins.

The histidine triad superfamily of nucleotide-binding proteins. Research Abstract Details 

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The histidine triad superfamily of nucleotide-binding proteins. Abstract Text:

C Brenner,P Bieganowski,H C Pace,K Huebner,

Histidine triad (HIT) proteins were until recently a superfamily of proteins that shared only sequence motifs. Crystal structures of nucleotide-bound forms of histidine triad nucleotide-binding protein (Hint) demonstrated that the conserved residues in HIT proteins are responsible for their distinctive, dimeric, 10-stranded half-barrel structures that form two identical purine nucleotide-binding sites. Hint-related proteins, found in all forms of life, and fragile histidine triad (Fhit)-related proteins, found in animals and fungi, represent the two main branches of the HIT superfamily. Hint homologs are intracellular receptors for purine mononucleotides whose cellular function remains elusive. Fhit homologs bind and cleave diadenosine polyphosphates (Ap(n)A) such as ApppA and AppppA. Fhit-Ap(n)A complexes appear to function in a proapoptotic tumor suppression pathway in epithelial tissues. In invertebrates, Fhit homologs are encoded as fusion proteins with proteins related to plant and bacterial nitrilases that are candidate signaling partners in tumor suppression.

The histidine triad superfamily of nucleotide-binding proteins. Publishing Authors By Initials

C Brenner,P Bieganowski,HC Pace,K Huebner,

For similar biochemical phenomena, metabolism, and nutrition: biochemical phenomena: sequence homology: sequence homology, amino acid research abstracts see: biochemical phenomena, metabolism, and nutrition: biochemical phenomena: sequence homology: sequence homology, amino acid research

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The histidine triad superfamily of nucleotide-binding proteins. Journal Published:

PUBLICATION TYPE: Review

Journal: Journal of cellular physiology

VOLUME: 181

Page Numbers: 179-87

Journal Abbreviation: J. Cell. Physiol.

ISSN: 0021-9541

DAY: 25

MONTH: Nov

YEAR: 1999

The histidine triad superfamily of nucleotide-binding proteins. Information

Number of References: 54

LANGUAGE: eng

NlmUniqueID: 50222

The histidine triad superfamily of nucleotide-binding proteins. Keywords Mesh Terms:

KEYWORDS: Sequence Homology, Amino Acid

MESH TERMS: metabolism

Chemical & Substance for Abstract: The histidine triad superfamily of nucleotide-binding proteins. Information

Substance Name: Hydrolases

Registry Number: EC 3.-

Grant and Affiliation Information for The histidine triad superfamily of nucleotide-binding proteins.

AFFILIATION: Kimmel Cancer Institute, Thomas Jefferson University, Philadelphia, Pennsylvania, USA.

Country: UNITED STATES

AGENCY: United States NCI

GRANT: R01 CA075954-03

ACRONYM: CA

MEDLINETA: J Cell Physiol

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