The haemocompatibility of polyurethane-hyaluronic acid copolymers.

The haemocompatibility of polyurethane-hyaluronic acid copolymers. Research Abstract Details 

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The haemocompatibility of polyurethane-hyaluronic acid copolymers. Abstract Text:

Fangmin Xu,John C Nacker,Wendy C Crone,Kristyn S Masters,Fangmin Xu,John C Nacker,Wendy C Crone,Kristyn S Masters,Fangmin Xu,John C Nacker,Wendy C Crone,Kristyn S Masters,

Despite decades of research into haemocompatible biomaterials, there remain surprisingly few materials that can be used in blood-contacting applications. We have synthesized copolymers of polyurethane (PU) with hyaluronic acid (HA) with the goal of creating materials that incorporate an inherently non-thrombogenic, biological component into the bulk polymer structure. HA was incorporated into the polymer backbone as a chain extender during PU synthesis, and the physical and biological properties of the resulting copolymer were directly controlled by the HA content. Increases in HA content led to a linear increase in hydrophilicity (R(2)=0.993) and corresponding increase in surface energy compared to PU controls. Elastic modulus also increased with HA content (p<0.001), while surface roughness did not significantly differ from PU controls for most PU-HA formulations. Incorporation of HA resulted in negligible platelet adhesion to the PU-HA (p<0.001), representing a 20-fold decrease in platelet adhesion compared to PU. Red blood cell adhesion also decreased with increasing HA content (p<0.001). The PU-HA materials were cytocompatible and supported endothelial cell adhesion and viability. Thus, we have demonstrated the synthesis of a copolymer whose physical and biological properties are easily tailored, and whose potent anti-thrombogenic properties demonstrate its great promise for use in vascular applications.

The haemocompatibility of polyurethane-hyaluronic acid copolymers. Publishing Authors By Initials

F Xu,JC Nacker,WC Crone,KS Masters,F Xu,JC Nacker,WC Crone,KS Masters,F Xu,JC Nacker,WC Crone,KS Masters,

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The haemocompatibility of polyurethane-hyaluronic acid copolymers. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Biomaterials

VOLUME: 29

Page Numbers: 150-60

Journal Abbreviation: Biomaterials

ISSN: 0142-9612

DAY: 23

MONTH: 10

YEAR: 2007

The haemocompatibility of polyurethane-hyaluronic acid copolymers. Information

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LANGUAGE: eng

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Grant and Affiliation Information for The haemocompatibility of polyurethane-hyaluronic acid copolymers.

AFFILIATION: Department of Biomedical Engineering, University of Wisconsin-Madison, 1550 Engineering Drive, #2152, Madison, WI 53706, USA.

Country: England

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MEDLINETA: Biomaterials

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