The gut takes nearly all: threonine kinetics in infants.

The gut takes nearly all: threonine kinetics in infants. Research Abstract Details 

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The gut takes nearly all: threonine kinetics in infants. Abstract Text:

Sophie R D van der Schoor,Darcos L Wattimena,Jan Huijmans,Andras Vermes,Johannes B van Goudoever,Sophie R D van der Schoor,Darcos L Wattimena,Jan Huijmans,Andras Vermes,Johannes B van Goudoever,

BACKGROUND: Threonine is an essential amino acid that is abundantly present in intestinally produced glycoproteins. Animal studies show that intestinal first-pass threonine metabolism is high, particularly during a restricted enteral protein intake. OBJECTIVE: The objective of the study was to quantify intestinal first-pass threonine metabolism in preterm infants during full enteral feeding and during restricted enteral intake. DESIGN: Eight preterm infants (x +/- SD birth weight: 1.1 +/- 0.1 kg; gestational age: 29 +/- 2 wk) were studied during 2 periods. During period A, 40% of total intake was administered enterally and 60% was administered parenterally. Total threonine intake was 58 +/- 6 micromol kg(-1) h(-1). During period B, the infants received full enteral feeding, and the total threonine intake was 63 +/- 6 micromol kg(-1) h(-1). Dual stable-isotope tracer techniques were used to assess splanchnic and whole-body threonine kinetics. RESULTS: The fractional first-pass threonine uptake by the intestine was remarkably high in both periods: 82 +/- 6% during partial enteral feeding and 70 +/- 6% during full enteral feeding. Net threonine retention was not affected by the route of feeding. CONCLUSION: In preterm infants, the splanchnic tissues extract a very large amount of the dietary threonine intake, which indicates a high obligatory visceral need for threonine, presumably for the purposes of synthesis.

The gut takes nearly all: threonine kinetics in infants. Publishing Authors By Initials

SR van der Schoor,DL Wattimena,J Huijmans,A Vermes,JB van Goudoever,SR van der Schoor,DL Wattimena,J Huijmans,A Vermes,JB van Goudoever,

For similar body regions: viscera research abstracts see: body regions: viscera research

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The gut takes nearly all: threonine kinetics in infants. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: The American journal of clinical nutrition

VOLUME: 86

Page Numbers: 1132-8

Journal Abbreviation: Am. J. Clin. Nutr.

ISSN: 0002-9165

DAY: 29

MONTH: Oct

YEAR: 2007

The gut takes nearly all: threonine kinetics in infants. Information

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LANGUAGE: eng

NlmUniqueID: 376027

The gut takes nearly all: threonine kinetics in infants. Keywords Mesh Terms:

KEYWORDS: Viscera

MESH TERMS: metabolism

Chemical & Substance for Abstract: The gut takes nearly all: threonine kinetics in infants. Information

Substance Name: Threonine

Registry Number: 72-19-5

Grant and Affiliation Information for The gut takes nearly all: threonine kinetics in infants.

AFFILIATION: Department of Pediatrics, Division of Neonatology, Erasmus MC-Sophia Children's Hospital, Erasmus University, Rotterdam, Netherlands.

Country: United States

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MEDLINETA: Am J Clin Nutr

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