The gut-brain peptide neuromedin U is involved in the mammalian circadian oscillator system.

The gut-brain peptide neuromedin U is involved in the mammalian circadian oscillator system. Research Abstract Details 

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The gut-brain peptide neuromedin U is involved in the mammalian circadian oscillator system. Abstract Text:

Keiko Nakahara,Reiko Hanada,Noboru Murakami,Hitoshi Teranishi,Hideko Ohgusu,Nobuhiro Fukushima,Maiko Moriyama,Takanori Ida,Kenji Kangawa,Masayasu Kojima,

Immunohistochemical analysis revealed the presence of a gut-brain peptide, neuromedin U (NMU), in the suprachiasmatic nucleus (SCN), which is the site of the master circadian oscillator. The expression of NMU mRNA exhibited a circadian rhythm, with the peak expression in the SCN occurring at CT4-8h. The two NMU-binding receptors (NMU-R1 and NMU-R2) were also expressed in the SCN, but their phase angles were different. Intracerebroventricular injection (ICV) of NMU induced the expression of Fos protein in the SCN cells and caused a phase-dependent phase shift of the circadian locomotor activity rhythm. The magnitude of the phase shift was dose dependent. This NMU-induced phase shift was of the nonphotic type. Quantitative reverse transcriptase-polymerase chain reaction (RT-PCR) analysis revealed increases in the expression in the SCN of immediate early genes, such as c-fos, NGFI-A, NGFI-B, and JunB. Furthermore, ICV injection of NMU increased the expression of Per1, but not Per2, in the SCN. These results indicate that NMU may play some important role in the circadian oscillator by exerting an autocrine or paracrine action in the SCN.

The gut-brain peptide neuromedin U is involved in the mammalian circadian oscillator system. Publishing Authors By Initials

K Nakahara,R Hanada,N Murakami,H Teranishi,H Ohgusu,N Fukushima,M Moriyama,T Ida,K Kangawa,M Kojima,

For similar proteins: transcription factors research abstracts see: proteins: transcription factors research

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The gut-brain peptide neuromedin U is involved in the mammalian circadian oscillator system. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Biochemical and biophysical research communication

VOLUME: 318

Page Numbers: 156-61

Journal Abbreviation: Biochem. Biophys. Res. Commun.

ISSN: 0006-291X

DAY: 21

MONTH: May

YEAR: 2004

The gut-brain peptide neuromedin U is involved in the mammalian circadian oscillator system. Information

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LANGUAGE: eng

NlmUniqueID: 372516

The gut-brain peptide neuromedin U is involved in the mammalian circadian oscillator system. Keywords Mesh Terms:

KEYWORDS: Transcription Factors

MESH TERMS: metabolism

Chemical & Substance for Abstract: The gut-brain peptide neuromedin U is involved in the mammalian circadian oscillator system. Information

Substance Name: neuromedin U

Registry Number: 117505-80-3

Grant and Affiliation Information for The gut-brain peptide neuromedin U is involved in the mammalian circadian oscillator system.

AFFILIATION: Department of Veterinary Physiology, Faculty of Agriculture, Miyazaki University, Miyazaki 889-2192, Japan.

Country: United States

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MEDLINETA: Biochem Biophys Res Commun

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