The GRV2/RME-8 protein of Arabidopsis functions in the late endocytic pathway and is required for vacuolar membrane flow.

The GRV2/RME-8 protein of Arabidopsis functions in the late endocytic pathway and is required for vacuolar membrane flow. Research Abstract Details 

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The GRV2/RME-8 protein of Arabidopsis functions in the late endocytic pathway and is required for vacuolar membrane flow. Abstract Text:

Rebecca A Silady,David W Ehrhardt,Karen Jackson,Christine Faulkner,Karl Oparka,Chris R Somerville,Rebecca A Silady,David W Ehrhardt,Karen Jackson,Christine Faulkner,Karl Oparka,Chris R Somerville,Rebecca A Silady,David W Ehrhardt,Karen Jackson,Christine Faulkner,Karl Oparka,Chris R Somerville,

The gravitropism defective 2 (grv2) mutants of Arabidopsis thaliana were previously characterized as exhibiting shoot agravitropism resulting from mutations in a homolog of the Caenorhabditis elegans RECEPTOR-MEDIATED ENDOCYTOSIS-8 (RME-8) gene, which is required in C. elegans for endocytosis. A fluorescent protein fusion to the GRV2 protein localized to endosomes in transgenic plants, and vacuolar morphology was altered in grv2 mutants. A defect in vacuolar membrane dynamics provides a mechanistic explanation for the gravitropic defect, and may also account for the presence of an enlarged vacuole in early embryos, together with a nutrient requirement during seedling establishment. The GRV2-positive endosomes were sensitive to Wortmannin but not brefeldin A (BFA), consistent with GRV2 operating late in the endocytic pathway, prior to delivery of vesicles to the central vacuole. The specific enlargement of GRV2:YFP structures by Wortmannin, together with biochemical data showing that GRV2 co-fractionates with pre-vacuolar markers such as PEP12/SYP21, leads us to conclude that in plants GRV2/RME-8 functions in vesicle trafficking from the multivesicular body/pre-vacuolar compartment to the lytic vacuole.

The GRV2/RME-8 protein of Arabidopsis functions in the late endocytic pathway and is required for vacuolar membrane flow. Publishing Authors By Initials

RA Silady,DW Ehrhardt,K Jackson,C Faulkner,K Oparka,CR Somerville,RA Silady,DW Ehrhardt,K Jackson,C Faulkner,K Oparka,CR Somerville,RA Silady,DW Ehrhardt,K Jackson,C Faulkner,K Oparka,CR Somerville,

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The GRV2/RME-8 protein of Arabidopsis functions in the late endocytic pathway and is required for vacuolar membrane flow. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: The Plant journal : for cell and molecular biology

VOLUME: 53

Page Numbers: 29-41

Journal Abbreviation: Plant J.

ISSN: 0960-7412

DAY: 27

MONTH: 10

YEAR: 2007

The GRV2/RME-8 protein of Arabidopsis functions in the late endocytic pathway and is required for vacuolar membrane flow. Information

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LANGUAGE: eng

NlmUniqueID: 9207397

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Grant and Affiliation Information for The GRV2/RME-8 protein of Arabidopsis functions in the late endocytic pathway and is required for vacuolar membrane flow.

AFFILIATION: Department of Biological Sciences, Stanford University, Stanford, CA 94305, USA, and Department of Plant Biology, Carnegie Institution, 260 Panama Street, Stanford, CA 94305, USA.

Country: England

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MEDLINETA: Plant J

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