The Grainyhead-like epithelial transactivator Get-1/Grhl3 regulates epidermal terminal differentiation and interacts functionally with LMO4.

The Grainyhead-like epithelial transactivator Get-1/Grhl3 regulates epidermal terminal differentiation and interacts functionally with LMO4. Research Abstract Details 

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The Grainyhead-like epithelial transactivator Get-1/Grhl3 regulates epidermal terminal differentiation and interacts functionally with LMO4. Abstract Text:

Zhengquan Yu,Kevin K Lin,Ambica Bhandari,Joel A Spencer,Xiaoman Xu,Ning Wang,Zhongxian Lu,Gordon N Gill,Dennis R Roop,Philip Wertz,Bogi Andersen,

Defective permeability barrier is an important feature of many skin diseases and causes mortality in premature infants. To investigate the control of barrier formation, we characterized the epidermally expressed Grainyhead-like epithelial transactivator (Get-1)/Grhl3, a conserved mammalian homologue of Grainyhead, which plays important roles in cuticle development in Drosophila. Get-1 interacts with the LIM-only protein LMO4, which is co-expressed in the developing mammalian epidermis. The epidermis of Get-1(-/-) mice showed a severe barrier function defect associated with impaired differentiation of the epidermis, including defects of the stratum corneum, extracellular lipid composition and cell adhesion in the granular layer. The Get-1 mutation affects multiple genes linked to terminal differentiation and barrier function, including most genes of the epidermal differentiation complex. Get-1 therefore directly or indirectly regulates a broad array of epidermal differentiation genes encoding structural proteins, lipid metabolizing enzymes and cell adhesion molecules. Although deletion of the LMO4 gene had no overt consequences for epidermal development, the epidermal terminal differentiation defect in mice deleted for both Get-1 and LMO4 is much more severe than in Get-1(-/-) mice with striking impairment of stratum corneum formation. These findings indicate that the Get-1 and LMO4 genes interact functionally to regulate epidermal terminal differentiation.

The Grainyhead-like epithelial transactivator Get-1/Grhl3 regulates epidermal terminal differentiation and interacts functionally with LMO4. Publishing Authors By Initials

Z Yu,KK Lin,A Bhandari,JA Spencer,X Xu,N Wang,Z Lu,GN Gill,DR Roop,P Wertz,B Andersen,

For similar proteins: transcription factors research abstracts see: proteins: transcription factors research

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The Grainyhead-like epithelial transactivator Get-1/Grhl3 regulates epidermal terminal differentiation and interacts functionally with LMO4. Journal Published:

PUBLICATION TYPE: Research Support, U.S. Gov't,

Journal: Developmental biology

VOLUME: 299

Page Numbers: 122-36

Journal Abbreviation: Dev. Biol.

ISSN: 0012-1606

DAY: 21

MONTH: 07

YEAR: 2006

The Grainyhead-like epithelial transactivator Get-1/Grhl3 regulates epidermal terminal differentiation and interacts functionally with LMO4. Information

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LANGUAGE: eng

NlmUniqueID: 372762

The Grainyhead-like epithelial transactivator Get-1/Grhl3 regulates epidermal terminal differentiation and interacts functionally with LMO4. Keywords Mesh Terms:

KEYWORDS: Transcription Factors

MESH TERMS: metabolism

Chemical & Substance for Abstract: The Grainyhead-like epithelial transactivator Get-1/Grhl3 regulates epidermal terminal differentiation and interacts functionally with LMO4. Information

Substance Name: occludin

Registry Number: 0

Grant and Affiliation Information for The Grainyhead-like epithelial transactivator Get-1/Grhl3 regulates epidermal terminal differentiation and interacts functionally with LMO4.

AFFILIATION: Departments of Medicine and Biological Chemistry, University of California, Irvine, CA 92697-4030, USA.

Country: United States

AGENCY: United States NIAMS

GRANT: AR44882

ACRONYM: AR

MEDLINETA: Dev Biol

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