The glycosyltransferases of Mycobacterium tuberculosis - roles in the synthesis of arabinogalactan, lipoarabinomannan, and other glycoconjugates.

The glycosyltransferases of Mycobacterium tuberculosis - roles in the synthesis of arabinogalactan, lipoarabinomannan, and other glycoconjugates. Research Abstract Details 

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The glycosyltransferases of Mycobacterium tuberculosis - roles in the synthesis of arabinogalactan, lipoarabinomannan, and other glycoconjugates. Abstract Text:

Stefan Berg,Devinder Kaur,Mary Jackson,Patrick J Brennan,

Several human pathogens are to be found within the bacterial genus Mycobacterium, notably Mycobacterium tuberculosis, the causative agent of tuberculosis, one of the most threatening of human infectious diseases, with an annual lethality of about two million people. The characteristic mycobacterial cell envelope is the dominant feature of the biology of M. tuberculosis and other mycobacterial pathogens, based on sugars and lipids of exceptional structure. The cell wall consists of a peptidoglycan-arabinogalactan-mycolic acid complex beyond the plasma membrane. Free-standing lipids, lipoglycans, and proteins intercalate within this complex, complement the mycolic acid monolayer and may also appear in a capsular-like arrangement. The consequences of these structural oddities are an extremely robust and impermeable cell envelope. This review reflects on these entities from the perspective of their synthesis, particularly the structural and functional aspects of the glycosyltransferases (GTs) of M. tuberculosis, the dominating group of enzymes responsible for the terminal stages of their biosynthesis. Besides the many nucleotide-sugar dependent GTs with orthologs in prokaryotes and eukaryotes, M. tuberculosis and related species of the order Actinomycetales, in light of the highly lipophilic environment prevailing within the cell envelope, carry a significant number of GTs of the GT-C class dependent on polyprenyl-phosphate-linked sugars. These are of special emphasis in this review.

The glycosyltransferases of Mycobacterium tuberculosis - roles in the synthesis of arabinogalactan, lipoarabinomannan, and other glycoconjugates. Publishing Authors By Initials

S Berg,D Kaur,M Jackson,PJ Brennan,

For similar bacteria: gram-positive bacteria: actinobacteria: actinomycetales: mycobacteriaceae: mycobacterium: mycobacterium tuberculosis research abstracts see: bacteria: gram-positive bacteria: actinobacteria: actinomycetales: mycobacteriaceae: mycobacterium: mycobacterium tuberculosis research

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The glycosyltransferases of Mycobacterium tuberculosis - roles in the synthesis of arabinogalactan, lipoarabinomannan, and other glycoconjugates. Journal Published:

PUBLICATION TYPE: Review

Journal: Glycobiology

VOLUME: 17

Page Numbers: 35-56R

Journal Abbreviation: Glycobiology

ISSN: 0959-6658

DAY: 29

MONTH: 01

YEAR: 2007

The glycosyltransferases of Mycobacterium tuberculosis - roles in the synthesis of arabinogalactan, lipoarabinomannan, and other glycoconjugates. Information

Number of References: 172

LANGUAGE: eng

NlmUniqueID: 9104124

The glycosyltransferases of Mycobacterium tuberculosis - roles in the synthesis of arabinogalactan, lipoarabinomannan, and other glycoconjugates. Keywords Mesh Terms:

KEYWORDS: Mycobacterium tuberculosis

MESH TERMS: metabolism

Chemical & Substance for Abstract: The glycosyltransferases of Mycobacterium tuberculosis - roles in the synthesis of arabinogalactan, lipoarabinomannan, and other glycoconjugates. Information

Substance Name: Glycosyltransferases

Registry Number: EC 2.4.-

Grant and Affiliation Information for The glycosyltransferases of Mycobacterium tuberculosis - roles in the synthesis of arabinogalactan, lipoarabinomannan, and other glycoconjugates.

AFFILIATION: Department of Microbiology, Immunology, and Pathology, Colorado State University, Fort Collins, CO 80523, USA.

Country: England

AGENCY: United States NIAID

GRANT: AI-18357

ACRONYM: AI

MEDLINETA: Glycobiology

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