The GLUT9 Gene Is Associated with Serum Uric Acid Levels in Sardinia and Chianti Cohorts.

The GLUT9 Gene Is Associated with Serum Uric Acid Levels in Sardinia and Chianti Cohorts. Research Abstract Details 

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The GLUT9 Gene Is Associated with Serum Uric Acid Levels in Sardinia and Chianti Cohorts. Abstract Text:

Siguang Li,Serena Sanna,Andrea Maschio,Fabio Busonero,Gianluca Usala,Antonella Mulas,Sandra Lai,Mariano Dei,Marco ,Giuseppe Albai,Stefania Bandinelli,David Schlessinger,Edward Lakatta,Angelo Scuteri,Samer S Najjar,Jack Guralnik,Silvia Naitza,Laura Crisponi,Antonio Cao, Abecasis,Luigi Ferrucci,Manuela Uda,Wei-Min Chen,Ramaiah Nagaraja,

High serum uric acid levels elevate pro-inflammatory-state gout crystal arthropathy and place individuals at high risk for cardiovascular morbidity and mortality. Genome-wide scans in the genetically isolated Sardinian population identified variants associated with serum uric acid levels as a quantitative trait. They mapped within GLUT9, a Chromosome 4 glucose transporter gene predominantly expressed in liver and kidney. SNP rs6855911 showed the strongest association (p = 1.84 x 10(-16)), along with eight others (p = 7.75 x 10(-16) to 6.05 x 10(-11)). Individuals homozygous for the rare allele of rs6855911 (minor allele frequency = 0.26) had 0.6 mg/dl less uric acid than those homozygous for the common allele; the results were replicated in an unrelated cohort from Tuscany. Our results suggest that polymorphisms in GLUT9 could affect glucose metabolism and uric acid synthesis and/or renal reabsorption, influencing serum uric acid levels over a wide range of values.

The GLUT9 Gene Is Associated with Serum Uric Acid Levels in Sardinia and Chianti Cohorts. Publishing Authors By Initials

S Li,S Sanna,A Maschio,F Busonero,G Usala,A Mulas,S Lai,M Dei,M ,G Albai,S Bandinelli,D Schlessinger,E Lakatta,A Scuteri,SS Najjar,J Guralnik,S Naitza,L Crisponi,A Cao,G Abecasis,L Ferrucci,M Uda,WM Chen,R Nagaraja,

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The GLUT9 Gene Is Associated with Serum Uric Acid Levels in Sardinia and Chianti Cohorts. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: PLoS genetics

VOLUME: 3

Page Numbers: e194

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ISSN: 1553-7404

DAY: 31

MONTH: Nov

YEAR: 2007

The GLUT9 Gene Is Associated with Serum Uric Acid Levels in Sardinia and Chianti Cohorts. Information

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LANGUAGE: eng

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