The glial or neuronal fate choice of oligodendrocyte progenitors is modulated by their ability to acquire an epigenetic memory.

The glial or neuronal fate choice of oligodendrocyte progenitors is modulated by their ability to acquire an epigenetic memory. Research Abstract Details 

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The glial or neuronal fate choice of oligodendrocyte progenitors is modulated by their ability to acquire an epigenetic memory. Abstract Text:

Aixiao Liu,Yu R Han,Jiadong Li,Dongming Sun,Ming Ouyang,Mark R Plummer,Patrizia Casaccia-Bonnefil,

The identity of any cell type is determined by the specific pattern of gene expression. We show here that the ability of oligodendrocyte progenitors to acquire the identity of myelin-expressing cells or choose alternative fates is dependent on the activity of histone deacetylases. Using gene expression profiling, electrophysiological recordings, transplantation studies, and pharmacological inhibition, we demonstrate that specified NG2+ oligodendrocyte progenitors are plastic cells, whose decision to initiate an oligodendrocytic rather than astrocytic or neuronal program of gene expression requires the establishment of an epigenetic identity that is initiated by histone deacetylation.

The glial or neuronal fate choice of oligodendrocyte progenitors is modulated by their ability to acquire an epigenetic memory. Publishing Authors By Initials

A Liu,YR Han,J Li,D Sun,M Ouyang,MR Plummer,P Casaccia-Bonnefil,

For similar cells: stem cells research abstracts see: cells: stem cells research

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The glial or neuronal fate choice of oligodendrocyte progenitors is modulated by their ability to acquire an epigenetic memory. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: The Journal of neuroscience : the official journal

VOLUME: 27

Page Numbers: 7339-43

Journal Abbreviation: J. Neurosci.

ISSN: 1529-2401

DAY: 4

MONTH: Jul

YEAR: 2007

The glial or neuronal fate choice of oligodendrocyte progenitors is modulated by their ability to acquire an epigenetic memory. Information

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LANGUAGE: eng

NlmUniqueID: 8102140

The glial or neuronal fate choice of oligodendrocyte progenitors is modulated by their ability to acquire an epigenetic memory. Keywords Mesh Terms:

KEYWORDS: Stem Cells

MESH TERMS: physiology

Chemical & Substance for Abstract: The glial or neuronal fate choice of oligodendrocyte progenitors is modulated by their ability to acquire an epigenetic memory. Information

Substance Name: Histone Deacetylases

Registry Number: EC 3.5.1.-

Grant and Affiliation Information for The glial or neuronal fate choice of oligodendrocyte progenitors is modulated by their ability to acquire an epigenetic memory.

AFFILIATION: Department of Neuroscience and Cell Biology, R. Wood Johnson Medical School, Piscataway, New Jersey 08854, USA.

Country: United States

AGENCY: United States PHS

GRANT: R01 42925

ACRONYM: NS

MEDLINETA: J Neurosci

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