The ghost of selection past: rates of evolution and functional divergence of anciently duplicated genes.

The ghost of selection past: rates of evolution and functional divergence of anciently duplicated genes. Research Abstract Details 

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The ghost of selection past: rates of evolution and functional divergence of anciently duplicated genes. Abstract Text:

Y Van de Peer,J S Taylor,I Braasch,A Meyer,

The duplication of genes and even complete genomes may be a prerequisite for major evolutionary transitions and the origin of evolutionary novelties. However, the evolutionary mechanisms of gene evolution and the origin of novel gene functions after gene duplication have been a subject of many debates. Recently, we compiled 26 groups of orthologous genes, which included one gene from human, mouse, and chicken, one or two genes from the tetraploid Xenopus and two genes from zebrafish. Comparative analysis and mapping data showed that these pairs of zebrafish genes were probably produced during a fish-specific genome duplication that occurred between 300 and 450 Mya, before the teleost radiation (Taylor et al. 2001). As discussed here, many of these retained duplicated genes code for DNA binding proteins. Different models have been developed to explain the retention of duplicated genes and in particular the subfunctionalization model of Force et al. (1999) could explain why so many developmental control genes have been retained. Other models are harder to reconcile with this particular set of duplicated genes. Most genes seem to have been subjected to strong purifying selection, keeping properties such as charge and polarity the same in both duplicates, although some evidence was found for positive Darwinian selection, in particular for Hox genes. However, since only the cumulative pattern of nucleotide substitutions can be studied, clear indications of positive Darwinian selection or neutrality may be hard to find for such anciently duplicated genes. Nevertheless, an increase in evolutionary rate in about half of the duplicated genes seems to suggest that either positive Darwinian selection has occurred or that functional constraints have been relaxed at one point in time during functional divergence.

The ghost of selection past: rates of evolution and functional divergence of anciently duplicated genes. Publishing Authors By Initials

Y Van de Peer,JS Taylor,I Braasch,A Meyer,

For similar animals: chordata: vertebrates: fishes: cypriniformes: cyprinidae: zebrafish research abstracts see: animals: chordata: vertebrates: fishes: cypriniformes: cyprinidae: zebrafish research

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MEDLINE DATE: 2001 Oct-Nov

The ghost of selection past: rates of evolution and functional divergence of anciently duplicated genes. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Journal of molecular evolution

VOLUME: 53

Page Numbers: 436-46

Journal Abbreviation: J. Mol. Evol.

ISSN: 0022-2844

DAY: 19

MONTH: 11

YEAR: 2007

The ghost of selection past: rates of evolution and functional divergence of anciently duplicated genes. Information

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LANGUAGE: eng

NlmUniqueID: 360051

The ghost of selection past: rates of evolution and functional divergence of anciently duplicated genes. Keywords Mesh Terms:

KEYWORDS: Zebrafish

MESH TERMS: genetics

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Substance Name: bone morphogenetic protein 2

Registry Number: 0

Grant and Affiliation Information for The ghost of selection past: rates of evolution and functional divergence of anciently duplicated genes.

AFFILIATION: Department of Biology, University of Konstanz, 78457 Konstanz, Germany. yvdp@gengenp.rug.ac.be

Country: United States

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MEDLINETA: J Mol Evol

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