[The genotoxic effects of cadmium studied in vivo]

[The genotoxic effects of cadmium studied in vivo] Research Abstract Details 

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[The genotoxic effects of cadmium studied in vivo] Abstract Text:

K V Privezentsev,N P Sirota,A I Gaziev,

Genetic effects of cadmium were studied using nucleoid microelectrophoresis of separate cells and micronucleus test. It was shown that cadmium chloride (in the range 2 x 10(-5) - 2 x 10(-1) mg of Cd2+/ml) induced nucleoid relaxation in peripheral blood lymphocytes (PBL) after one hour incubation in vitro. Single injection of cadmium chloride (1 mg of Cd2+/kg of body wt.) induced DNA damages in PBL, splenocytes and thymocytes. The dynamics of DNA damage and repair was distinct in different cells. The same dose induced an increase in the frequency of micronucleated bone marrow erythrocytes in mice. It is suggested that the mechanism of cadmium genotoxicity is due to the single strand breaks in DNA through the direct cadmium-DNA interactions as well as to the action of incision nucleases and/or DNA-glicosilases during DNA repair.

[The genotoxic effects of cadmium studied in vivo] Publishing Authors By Initials

KV Privezentsev,NP Sirota,AI Gaziev,

For similar natural sciences: time: time factors research abstracts see: natural sciences: time: time factors research

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[The genotoxic effects of cadmium studied in vivo] Journal Published:

PUBLICATION TYPE: Journal Article

Journal: T?Sitologii?a i genetika

VOLUME: 30

Page Numbers: 45-51

Journal Abbreviation:

ISSN: 0564-3783

DAY: 15

MONTH: 02

YEAR: 2008

[The genotoxic effects of cadmium studied in vivo] Information

Number of References:

LANGUAGE: rus

NlmUniqueID: 101671

[The genotoxic effects of cadmium studied in vivo] Keywords Mesh Terms:

KEYWORDS: Time Factors

MESH TERMS: methods

Chemical & Substance for Abstract: [The genotoxic effects of cadmium studied in vivo] Information

Substance Name: Cadmium Chloride

Registry Number: 10108-64-2

Grant and Affiliation Information for [The genotoxic effects of cadmium studied in vivo]

AFFILIATION:

Country: UKRAINE

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MEDLINETA: Tsitol Genet

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