The genetics of frontotemporal lobar degeneration.

The genetics of frontotemporal lobar degeneration. Research Abstract Details 

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The genetics of frontotemporal lobar degeneration. Abstract Text:

Rosa Rademakers,Mike Hutton,

The clinical disorders associated with frontotemporal lobar degeneration (FTLD) are increasingly recognized as an important cause of early-onset dementia. Patients usually present with progressive changes in personality, behavior, or language, progressing to general cognitive impairment and ultimately death. In the past decade, improved clinical and histopathologic characterization uncovered extensive heterogeneity, and multiple clinical and pathologic FTLD subtypes were defined. Simultaneously, the discovery of four causal FTLD genes emphasized the genetic complexity associated with FTLD. More recently, the field of FTLD has gained increased attention as a result of two major findings. First, mutations in the progranulin gene (PGRN) were recognized as a major cause of FTLD with ubiquitin-positive and tau-negative inclusions (FTLD-U), and subsequently the TAR DNA-binding protein-43 (TDP-43) was identified as a key protein within the ubiquitinated inclusions in FTLD-U and amyotrophic lateral sclerosis (ALS). In this report, we outline the progress made in the study of the genetic etiologies and neuropathologic substrates in FTLD.

The genetics of frontotemporal lobar degeneration. Publishing Authors By Initials

R Rademakers,M Hutton,

For similar proteins: nerve tissue proteins research abstracts see: proteins: nerve tissue proteins research

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The genetics of frontotemporal lobar degeneration. Journal Published:

PUBLICATION TYPE: Review

Journal: Current neurology and neuroscience reports

VOLUME: 7

Page Numbers: 434-42

Journal Abbreviation:

ISSN: 1528-4042

DAY: 26

MONTH: Sep

YEAR: 2007

The genetics of frontotemporal lobar degeneration. Information

Number of References: 73

LANGUAGE: eng

NlmUniqueID: 100931790

The genetics of frontotemporal lobar degeneration. Keywords Mesh Terms:

KEYWORDS: Nerve Tissue Proteins

MESH TERMS: genetics

Chemical & Substance for Abstract: The genetics of frontotemporal lobar degeneration. Information

Substance Name: Adenosine Triphosphatases

Registry Number: EC 3.6.1.-

Grant and Affiliation Information for The genetics of frontotemporal lobar degeneration.

AFFILIATION: Department of Neuroscience, Mayo Clinic College of Medicine, 4500 San Pablo Road, Jacksonville, FL 32224, USA. rademakers.rosa@mayo.edu

Country: United States

AGENCY: United States NIA

GRANT: R01 AG026251

ACRONYM: AG

MEDLINETA: Curr Neurol Neurosci Rep

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