The gastroduodenal branch of the common hepatic vagus regulates voluntary lard intake, fat deposition, and plasma metabolites in streptozotocin-diabetic rats.

The gastroduodenal branch of the common hepatic vagus regulates voluntary lard intake, fat deposition, and plasma metabolites in streptozotocin-diabetic rats. Research Abstract Details 

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The gastroduodenal branch of the common hepatic vagus regulates voluntary lard intake, fat deposition, and plasma metabolites in streptozotocin-diabetic rats. Abstract Text:

James P Warne,Michelle T Foster,Hart F Horneman,Norman C Pecoraro,Hanna K de Jong,Abigail B Ginsberg,Susan F Akana,Mary F Dallman,James P Warne,Michelle T Foster,Hart F Horneman,Norman C Pecoraro,Hanna K de Jong,Abigail B Ginsberg,Susan F Akana,Mary F Dallman,

The common hepatic branch of the vagus nerve negatively regulates lard intake in rats with streptozotocin (STZ)-induced, insulin-dependent diabetes. However, this branch consists of two subbranches: the hepatic branch proper, which serves the liver, and the gastroduodenal branch, which serves the distal stomach, pancreas, and duodenum. The aim of this study was to determine whether the gastroduodenal branch specifically regulates voluntary lard intake. We performed a gastroduodenal branch vagotomy (GV) on nondiabetic, STZ-diabetic, and STZ-diabetic insulin-treated groups of rats and compared them with sham-operated counterparts. All rats had high steady-state corticosterone levels to maximize lard intake. Five days after surgery, all rats were provided with the choice of chow or lard to eat for another 5 days. STZ-diabetes resulted in a reduction in lard intake that was partially rescued by either GV or insulin treatment. Patterns of white adipose tissue (WAT) deposition differed after GV- and insulin-induced lard intake, with subcutaneous WAT increasing exclusively after the former and mesenteric WAT increasing exclusively in the latter. GV also prevented the insulin-induced reduction in the STZ-elevated plasma glucagon, triglycerides, free fatty acids, and total ketone bodies but did not alter the effect of insulin-induced reduction of plasma glucose levels. These data suggest that the gastroduodenal branch of the vagus inhibits lard intake and regulates WAT deposition and plasma metabolite levels in STZ-diabetic rats.

The gastroduodenal branch of the common hepatic vagus regulates voluntary lard intake, fat deposition, and plasma metabolites in streptozotocin-diabetic rats. Publishing Authors By Initials

JP Warne,MT Foster,HF Horneman,NC Pecoraro,HK de Jong,AB Ginsberg,SF Akana,MF Dallman,JP Warne,MT Foster,HF Horneman,NC Pecoraro,HK de Jong,AB Ginsberg,SF Akana,MF Dallman,

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The gastroduodenal branch of the common hepatic vagus regulates voluntary lard intake, fat deposition, and plasma metabolites in streptozotocin-diabetic rats. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: American journal of physiology. Endocrinology and

VOLUME: 294

Page Numbers: E190-200

Journal Abbreviation: Am. J. Physiol. Endocrinol. Me

ISSN: 0193-1849

DAY: 30

MONTH: 10

YEAR: 2007

The gastroduodenal branch of the common hepatic vagus regulates voluntary lard intake, fat deposition, and plasma metabolites in streptozotocin-diabetic rats. Information

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LANGUAGE: eng

NlmUniqueID: 100901226

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AFFILIATION: Dept. of Physiology, Box 0444, Univ. of California San Francisco, 513 Parnassus Ave., San Francisco, CA 94143. james.warne@ucsf.edu).

Country: United States

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MEDLINETA: Am J Physiol Endocrinol Metab

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