The g.243A>G mutation in intron 17 of MUC4 is significantly associated with susceptibility/resistance to ETEC F4ab/ac infection in pigs.

The g.243A>G mutation in intron 17 of MUC4 is significantly associated with susceptibility/resistance to ETEC F4ab/ac infection in pigs. Research Abstract Details 

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The g.243A>G mutation in intron 17 of MUC4 is significantly associated with susceptibility/resistance to ETEC F4ab/ac infection in pigs. Abstract Text:

Q-L Peng,J Ren,X-M Yan,X Huang,H Tang,Y-Z Wang,B Zhang,L-S Huang,

Using a porcine radiation hybrid panel, we assigned the mucin 4 (MUC4) gene to SSC13q41, which harbours the enterotoxigenic Escherichia coli (ETEC) F4ab/ac receptor locus. In addition, we identified two SNPs in intron 17 of MUC4 (DQ124298:g.243A>G and DQ124298:g.334A>G) in the parental population of a White Duroc x Erhualian cross. Association analysis showed that the MUC4 g.243A>G mutation was strongly associated with ETEC F4ab/ac, and especially with F4ac adhesion phenotypes in the White Duroc x Erhualian resource population, indicating that this polymorphism was in a significant linkage disequlibrium with the ETEC F4ab/ac receptor locus. Because of different linkage disequlibrium values between the ETEC F4ab and F4ac adhesion phenotypes and the MUC4 g.243A>G mutation, we argue that the inheritance of F4ab and F4ac receptors might be under the control of two closely linked loci.

The g.243A>G mutation in intron 17 of MUC4 is significantly associated with susceptibility/resistance to ETEC F4ab/ac infection in pigs. Publishing Authors By Initials

QL Peng,J Ren,XM Yan,X Huang,H Tang,YZ Wang,B Zhang,LS Huang,

For similar animal diseases: swine diseases research abstracts see: animal diseases: swine diseases research

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The g.243A>G mutation in intron 17 of MUC4 is significantly associated with susceptibility/resistance to ETEC F4ab/ac infection in pigs. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Animal genetics

VOLUME: 38

Page Numbers: 397-400

Journal Abbreviation: Anim. Genet.

ISSN: 0268-9146

DAY: 9

MONTH: 06

YEAR: 2007

The g.243A>G mutation in intron 17 of MUC4 is significantly associated with susceptibility/resistance to ETEC F4ab/ac infection in pigs. Information

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LANGUAGE: eng

NlmUniqueID: 8605704

The g.243A>G mutation in intron 17 of MUC4 is significantly associated with susceptibility/resistance to ETEC F4ab/ac infection in pigs. Keywords Mesh Terms:

KEYWORDS: Swine Diseases

MESH TERMS: genetics

Chemical & Substance for Abstract: The g.243A>G mutation in intron 17 of MUC4 is significantly associated with susceptibility/resistance to ETEC F4ab/ac infection in pigs. Information

Substance Name: Mucins

Registry Number: 0

Grant and Affiliation Information for The g.243A>G mutation in intron 17 of MUC4 is significantly associated with susceptibility/resistance to ETEC F4ab/ac infection in pigs.

AFFILIATION: Key Laboratory for Animal Biotechnology of Jiangxi Province and the Ministry of Agriculture of China, Jiangxi Agricultural University, 330045, Nanchang, China.

Country: England

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MEDLINETA: Anim Genet

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