Vitamin D has roles in a variety of biological actions such as calcium homeostasis, cell proliferation and cell differentiation to many target tissues. Most of these biological actions of vitamin D are now considered to be exerted through the nuclear vitamin D receptor (VDR)-mediated control of target genes. VDR belongs to the nuclear hormone receptor superfamily and acts as a ligand-inducible transcription factor. For the ligand-induced transactivation of VDR, coactivator complexes have recently been shown to be essential. The function of VDR as a ligand-induced transcription factor is overviewed, and the phenotype of VDR gene knock-out mice and the VDR-mediated transcriptional and negative regulation of the key enzyme in vitamin D biosynthesis are also described, based mainly on our recent findings, to gain a better understanding of the function of VDR in the transcriptional control of vitamin D target genes.
The function of vitamin D receptor in vitamin D action. Publishing Authors By Initials
Grant and Affiliation Information for The function of vitamin D receptor in vitamin D action.
AFFILIATION: Institute of Molecular and Cellular Biosciences, The University of Tokyo, Yayoi-cho, Bunkyo-ku, Tokyo, 113-0032, Japan. uskato@mail.ecc.u-tokyo.ac.jp
Country: JAPAN
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MEDLINETA: J Biochem
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