The Flip-side of Cytoadherence: Immune Selection, Antigenic Variation and the var Genes of Plasmodium falciparum.

The Flip-side of Cytoadherence: Immune Selection, Antigenic Variation and the var Genes of Plasmodium falciparum. Research Abstract Details 

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The Flip-side of Cytoadherence: Immune Selection, Antigenic Variation and the var Genes of Plasmodium falciparum. Abstract Text:

C J Sutherland,

In areas where Plasmodium falciparum is endemic, the natural immunity acquired by people exposed to frequent malaria infection is likely to have a differential selective impact upon different parasite genotypes. It has been suggested that the immune response directed against the variant antigen PfEMP1, which is expressed on the infected erythrocyte surface, is a crucial determinant of parasite population structure and favours the existence of distinct strains, or Varotypes. Here, Colin Sutherland summarizes current knowledge of the var multigene family, which encodes the PfEMP1 variants, and suggests that this information may allow certain predictions of the strain hypothesis to be tested directly.

The Flip-side of Cytoadherence: Immune Selection, Antigenic Variation and the var Genes of Plasmodium falciparum. Publishing Authors By Initials

CJ Sutherland,

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The Flip-side of Cytoadherence: Immune Selection, Antigenic Variation and the var Genes of Plasmodium falciparum. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Parasitology today (Personal ed.)

VOLUME: 14

Page Numbers: 329-32

Journal Abbreviation: Parasitol. Today (Regul. Ed.)

ISSN: 0169-4758

DAY: 16

MONTH: Aug

YEAR: 1998

The Flip-side of Cytoadherence: Immune Selection, Antigenic Variation and the var Genes of Plasmodium falciparum. Information

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LANGUAGE: eng

NlmUniqueID: 8605563

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Grant and Affiliation Information for The Flip-side of Cytoadherence: Immune Selection, Antigenic Variation and the var Genes of Plasmodium falciparum.

AFFILIATION: Department of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, Keppel Street, London, UK WC1E 7HT.

Country: England

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MEDLINETA: Parasitol Today

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