The first genomewide interaction and locus-heterogeneity linkage scan in bipolar affective disorder: strong evidence of epistatic effects between loci on chromosomes 2q and 6q.

The first genomewide interaction and locus-heterogeneity linkage scan in bipolar affective disorder: strong evidence of epistatic effects between loci on chromosomes 2q and 6q. Research Abstract Details 

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The first genomewide interaction and locus-heterogeneity linkage scan in bipolar affective disorder: strong evidence of epistatic effects between loci on chromosomes 2q and 6q. Abstract Text:

Rami Abou Jamra,Robert Fuerst,Radka Kaneva,Guillermo Orozco Diaz,Fabio Rivas,Fermin Mayoral,Eudoxia Gay,Sebastian Sans,Maria Jose Gonzalez,Susana Gil,Francisco Cabaleiro,Francisco Del Rio,Fermin Perez,Jesus Haro,Georg Auburger,Vihra Milanova,Christian Kostov,Vesselin Chorbov,Vessela Stoyanova,Amelia Nikolova-Hill,George Onchev,Ivo Kremensky,Assen Jablensky,Thomas G Schulze,Peter Propping,Marcella Rietschel,Markus M Nothen,Sven Cichon,Thomas F Wienker,Johannes Schumacher,Rami Abou Jamra,Robert Fuerst,Radka Kaneva,Guillermo Orozco Diaz,Fabio Rivas,Fermin Mayoral,Eudoxia Gay,Sebastian Sans,Maria Jose Gonzalez,Susana Gil,Francisco Cabaleiro,Francisco Del Rio,Fermin Perez,Jesus Haro,Georg Auburger,Vihra Milanova,Christian Kostov,Vesselin Chorbov,Vessela Stoyanova,Amelia Nikolova-Hill,George Onchev,Ivo Kremensky,Assen Jablensky,Thomas G Schulze,Peter Propping,Marcella Rietschel,Markus M Nothen,Sven Cichon,Thomas F Wienker,Johannes Schumacher,

We present the first genomewide interaction and locus-heterogeneity linkage scan in bipolar affective disorder (BPAD), using a large linkage data set (52 families of European descent; 448 participants and 259 affected individuals). Our results provide the strongest interaction evidence between BPAD genes on chromosomes 2q22-q24 and 6q23-q24, which was observed symmetrically in both directions (nonparametric LOD [NPL] scores of 7.55 on 2q and 7.63 on 6q; P<.0001 and P=.0001, respectively, after a genomewide permutation procedure). The second-best BPAD interaction evidence was observed between chromosomes 2q22-q24 and 15q26. Here, we also observed a symmetrical interaction (NPL scores of 6.26 on 2q and 4.59 on 15q; P=.0057 and .0022, respectively). We covered the implicated regions by genotyping additional marker sets and performed a detailed interaction linkage analysis, which narrowed the susceptibility intervals. Although the heterogeneity analysis produced less impressive results (highest NPL score of 3.32) and a less consistent picture, we achieved evidence of locus heterogeneity at chromosomes 2q, 6p, 11p, 13q, and 22q, which was supported by adjacent markers within each region and by previously reported BPAD linkage findings. Our results provide systematic insights in the framework of BPAD epistasis and locus heterogeneity, which should facilitate gene identification by the use of more-comprehensive cloning strategies.

The first genomewide interaction and locus-heterogeneity linkage scan in bipolar affective disorder: strong evidence of epistatic effects between loci on chromosomes 2q and 6q. Publishing Authors By Initials

R Abou Jamra,R Fuerst,R Kaneva,G Orozco Diaz,F Rivas,F Mayoral,E Gay,S Sans,MJ Gonzalez,S Gil,F Cabaleiro,F Del Rio,F Perez,J Haro,G Auburger,V Milanova,C Kostov,V Chorbov,V Stoyanova,A Nikolova-Hill,G Onchev,I Kremensky,A Jablensky,TG Schulze,P Propping,M Rietschel,MM Nothen,S Cichon,TF Wienker,J Schumacher,R Abou Jamra,R Fuerst,R Kaneva,G Orozco Diaz,F Rivas,F Mayoral,E Gay,S Sans,MJ Gonzalez,S Gil,F Cabaleiro,F Del Rio,F Perez,J Haro,G Auburger,V Milanova,C Kostov,V Chorbov,V Stoyanova,A Nikolova-Hill,G Onchev,I Kremensky,A Jablensky,TG Schulze,P Propping,M Rietschel,MM Nothen,S Cichon,TF Wienker,J Schumacher,

For similar genetic phenomena: linkage (genetics) research abstracts see: genetic phenomena: linkage (genetics) research

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The first genomewide interaction and locus-heterogeneity linkage scan in bipolar affective disorder: strong evidence of epistatic effects between loci on chromosomes 2q and 6q. Journal Published:

PUBLICATION TYPE: Research Support, U.S. Gov't,

Journal: American journal of human genetics

VOLUME: 81

Page Numbers: 974-86

Journal Abbreviation: Am. J. Hum. Genet.

ISSN: 0002-9297

DAY: 17

MONTH: 09

YEAR: 2007

The first genomewide interaction and locus-heterogeneity linkage scan in bipolar affective disorder: strong evidence of epistatic effects between loci on chromosomes 2q and 6q. Information

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LANGUAGE: eng

NlmUniqueID: 370475

The first genomewide interaction and locus-heterogeneity linkage scan in bipolar affective disorder: strong evidence of epistatic effects between loci on chromosomes 2q and 6q. Keywords Mesh Terms:

KEYWORDS: Linkage (Genetics)

MESH TERMS: genetics

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Substance Name: Genetic Markers

Registry Number: 0

Grant and Affiliation Information for The first genomewide interaction and locus-heterogeneity linkage scan in bipolar affective disorder: strong evidence of epistatic effects between loci on chromosomes 2q and 6q.

AFFILIATION: Institute of Human Genetics, University of Bonn, Bonn, Germany.

Country: United States

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MEDLINETA: Am J Hum Genet

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