[The expression of CXCR4 on acute leukemia cells and its implication for extramedullary infiltration]

[The expression of CXCR4 on acute leukemia cells and its implication for extramedullary infiltration] Research Abstract Details 

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[The expression of CXCR4 on acute leukemia cells and its implication for extramedullary infiltration] Abstract Text:

Sheng Li,Zi-xing Chen,Wei Wang,Jian-nong Chen,Jian-xin Fu,Li Yao,

OBJECTIVE: To study the expression of CXCR4 in acute leukemic cells and its clinical significance. METHOD: Bone marrow samples from 73 acute leukemia patients and leukemic cell lines were investigated by flow cytometry (FCM), the expression of SDF-1 in human marrow stromal cells and meninges were studied by using reverse transcription polymerase chain reaction (RT-PCR). Adhesion, migration and invasion of U937, NB4 and K562 cells were studied in vitro. RESULTS: The expression rates of CXCR4 in ALL and AML patients was 65.6% and 17.1%, respectively. And it was 0.2%, 41.0% and 52.0% in K562, U937 and NB4 cells, respectively. The extramedullary infiltration rates were 61.9% and 18.2% for CXCR4 positive and negative groups of ALL, respectively (P < 0.05); while in AML, the number of peripheral white blood cells in CXCR4 positive group was lower than that in CXCR4 negative group (P < 0.05). SDF-1alpha could enhance the adhesion, migration and invasion capacity of leukemic cells in vitro. CONCLUSION: Overexpression of CXCR4 in AL cells might be the molecular mechanism of extramedullary infiltration in leukemia.

[The expression of CXCR4 on acute leukemia cells and its implication for extramedullary infiltration] Publishing Authors By Initials

S Li,ZX Chen,W Wang,JN Chen,JX Fu,L Yao,

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[The expression of CXCR4 on acute leukemia cells and its implication for extramedullary infiltration] Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Zhonghua xue ye xue za zhi = Zhonghua xueyexue zaz

VOLUME: 25

Page Numbers: 405-8

Journal Abbreviation: Zhonghua Xue Ye Xue Za Zhi

ISSN: 0253-2727

DAY: 9

MONTH: Jul

YEAR: 2004

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LANGUAGE: chi

NlmUniqueID: 8212398

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AFFILIATION: The First Affiliated Hospital of Soochow University, Suzhou 215006, China.

Country: China

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MEDLINETA: Zhonghua Xue Ye Xue Za Zhi

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