The expression level of luciferase within tumour cells can alter tumour growth upon in vivo bioluminescence imaging.

The expression level of luciferase within tumour cells can alter tumour growth upon in vivo bioluminescence imaging. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

The expression level of luciferase within tumour cells can alter tumour growth upon in vivo bioluminescence imaging. Abstract Text:

Susan Brutkiewicz,Marc Mendonca,Keith Stantz,Kathleen Comerford,Robert Bigsby,Gary Hutchins,Mark Goebl,Maureen Harrington,

In vivo bioluminescence imaging is becoming a very important tool for the study of a variety of cellular and molecular events or disease processes in living systems. In vivo bioluminescence imaging is based on the detection of light emitted from within an animal. The light is generated as a product of the luciferase-luciferin reaction taking place in a cell. In this study, we implanted mice with tumour cells expressing either a high or a low level of luciferase. In vivo bioluminescence imaging was used to follow tumour progression. Repeated luciferin injection and imaging of high and low luciferase-expressing tumours was performed. While low luciferase-expressing tumours grew similarly to vector controls, growth of the high luciferase-expressing tumours was severely inhibited. The observation that a high level of luciferase expression will inhibit tumour cell growth when an animal is subjected to serial in vivo bioluminescence imaging is potentially an important factor in designing these types of studies.

The expression level of luciferase within tumour cells can alter tumour growth upon in vivo bioluminescence imaging. Publishing Authors By Initials

S Brutkiewicz,M Mendonca,K Stantz,K Comerford,R Bigsby,G Hutchins,M Goebl,M Harrington,

For similar neoplasms: neoplasms, experimental research abstracts see: neoplasms: neoplasms, experimental research

PUBMED ID PMID:

MEDLINE DATE:

The expression level of luciferase within tumour cells can alter tumour growth upon in vivo bioluminescence imaging. Journal Published:

PUBLICATION TYPE: Research Support, U.S. Gov't,

Journal: Luminescence : the journal of biological and chemi

VOLUME: 22

Page Numbers: 221-8

Journal Abbreviation:

ISSN: 1522-7235

DAY: 3

MONTH: 12

YEAR: 2007

The expression level of luciferase within tumour cells can alter tumour growth upon in vivo bioluminescence imaging. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 100889025

The expression level of luciferase within tumour cells can alter tumour growth upon in vivo bioluminescence imaging. Keywords Mesh Terms:

KEYWORDS: Neoplasms, Experimental

MESH TERMS: pathology

Chemical & Substance for Abstract: The expression level of luciferase within tumour cells can alter tumour growth upon in vivo bioluminescence imaging. Information

Substance Name: Luciferases

Registry Number: EC 1.13.12.-

Grant and Affiliation Information for The expression level of luciferase within tumour cells can alter tumour growth upon in vivo bioluminescence imaging.

AFFILIATION: Department of Obstetrics and Gynecology, Indiana University School of Medicine, Indianapolis, IN 46202, USA.

Country: England

AGENCY: United States NCI

GRANT: 1 R41 CA103566-01

ACRONYM: CA

MEDLINETA: Luminescence

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

The expression level of luciferase within tumour cells can alter tumour growth upon in vivo bioluminescence imaging Related Publications

• Advances in uveitis treatment.
• Age and body size influence male sperm capacity of the dengue vector Aedes aegypti (Diptera: Culicidae).
• Alkali metal complexes of a phosphine-borane-stabilised carbanion: influence of co-ligands on structure.
• Analysis of formant frequencies in patients with oral or oropharyngeal cancers treated by glossectomy.
• Changing i.v.s: kids are different.
• Combining radiation and cancer gene therapy: a potential marriage of physical and biological targeting?
• Dosimetric problems of radiotherapy to synchronous bilateral acinic cell carcinoma of parotid glands.
• Effect of autologous platelet gel on early and late graft fusion in anterior cervical spine surgery.
• Fatal brain stem event complicating acute pancreatitis.
• Is novel wheel inhibition of per1 and per2 expression linked to phase shift occurrence?
• Let there be "more" light: enhancement of light actions on the circadian system through non-photic pathways.
• Murine Pif1 interacts with telomerase and is dispensable for telomere function in vivo.
• Mycoplasma gallisepticum infection in house finches (Carpodacus mexicanus) affects mosquito blood feeding patterns.
• Neuropeptide Y differentially suppresses per1 and per2 mRNA induced by light in the suprachiasmatic nuclei of the golden hamster.
• Neuropeptide Y rapidly reduces Period 1 and Period 2 mRNA levels in the hamster suprachiasmatic nucleus.
• New devices for CTO revascularization.
• Non-aqueous synthetic methodology for TiW(5) polyoxometalates: protonolysis of [(MeO)TiW(5)O(18)](3-) with alcohols, water and phenols.
• OP01.02: First trimester arterial wave analysis compared with first trimester uterine artery Doppler as a tool for predicting pre-eclampsia.
• OP20.14: Does maternal calcium supplementation affect fetal blood flow?
• Ongoing risk behavior among persons with HIV in medical care.
• P41.05: Prediction of pre-eclampsia using a combination of first trimester arterial pulse wave analysis and second trimester uterine artery Doppler waveform.
• PPARS and Obesity.
• Postlaryngectomy vocal rehabilitation: assessment using a validated questionnaire in 51 patients.
• Presurgical psychiatric evaluations of candidates for bariatric surgery, part 1: reliability and reasons for and frequency of exclusion.
• Synthesis and reactivity of the methoxozirconium pentatungstate (nBu4N)6[{(mu-MeO)ZrW5O18}2]: insights into proton-transfer reactions, solution dynamics, and assembly of {ZrW5O18}2- building blocks.
• The collection and use of funds from civil money penalties and fines from nursing homes.
• The expression level of luciferase within tumour cells can alter tumour growth upon in vivo bioluminescence imaging.
• Timing of death and myocardial infarction in patients with non-ST elevation acute coronary syndromes: insights from randomized clinical trials.
• Transformation of the discriminative and eliciting functions of generalized relational stimuli.
• Voice-related Quality of Life in Laryngectomees: Assessment Using the VHI and V-RQOL Symptom Scales.