The expression and prognostic significance of bone morphogenetic protein-2 in patients with malignant fibrous histiocytoma.

The expression and prognostic significance of bone morphogenetic protein-2 in patients with malignant fibrous histiocytoma. Research Abstract Details 

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The expression and prognostic significance of bone morphogenetic protein-2 in patients with malignant fibrous histiocytoma. Abstract Text:

N Asano,T Yamakazi,M Seto,A Matsumine,H Yoshikawa,A Uchida,N Asano,T Yamakazi,M Seto,A Matsumine,H Yoshikawa,A Uchida,

We investigated the rates of expression of bone morphogenetic protein-2 (BMP-2) in 29 adult patients with high-grade malignant fibrous histiocytoma of soft tissue, using the BMP-2-specific monoclonal antibody, AbH3b2/17, and found that they ranged from 1.9% to 78.9%. The survival at five years of the groups expressing high (> or = 30%) and low (< 30%) levels of BMP-2 was 85.7% and 36.3%, respectively. Multivariable analysis showed that only BMP-2 had prognostic significance for continuous disease-free survival and for overall survival (p < 0.05). Our findings indicate that over-expression of BMP-2 in malignant fibrous histiocytoma of soft tissue is the most reliable prognostic indicator of the parameters assessed.

The expression and prognostic significance of bone morphogenetic protein-2 in patients with malignant fibrous histiocytoma. Publishing Authors By Initials

N Asano,T Yamakazi,M Seto,A Matsumine,H Yoshikawa,A Uchida,N Asano,T Yamakazi,M Seto,A Matsumine,H Yoshikawa,A Uchida,

For similar biological factors: biological markers: tumor markers, biological research abstracts see: biological factors: biological markers: tumor markers, biological research

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The expression and prognostic significance of bone morphogenetic protein-2 in patients with malignant fibrous histiocytoma. Journal Published:

PUBLICATION TYPE: Multicenter Study

Journal: The Journal of bone and joint surgery. British vo

VOLUME: 86

Page Numbers: 607-12

Journal Abbreviation:

ISSN: 0301-620X

DAY: 19

MONTH: May

YEAR: 2004

The expression and prognostic significance of bone morphogenetic protein-2 in patients with malignant fibrous histiocytoma. Information

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LANGUAGE: eng

NlmUniqueID: 375355

The expression and prognostic significance of bone morphogenetic protein-2 in patients with malignant fibrous histiocytoma. Keywords Mesh Terms:

KEYWORDS: Tumor Markers, Biological

MESH TERMS: metabolism

Chemical & Substance for Abstract: The expression and prognostic significance of bone morphogenetic protein-2 in patients with malignant fibrous histiocytoma. Information

Substance Name: bone morphogenetic protein 2

Registry Number: 0

Grant and Affiliation Information for The expression and prognostic significance of bone morphogenetic protein-2 in patients with malignant fibrous histiocytoma.

AFFILIATION: Department of Orthopaedic Surgery, Mie University Medical School, Faculty of Medicine, Tsu-City, Mie Prefecture, Japan.

Country: England

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MEDLINETA: J Bone Joint Surg Br

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