The expression and functions of glycoconjugates in neural stem cells.

The expression and functions of glycoconjugates in neural stem cells. Research Abstract Details 

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The expression and functions of glycoconjugates in neural stem cells. Abstract Text:

Makoto Yanagisawa,Robert K Yu,

The mammalian central nervous system is organized by a variety of cells such as neurons and glial cells. These cells are generated from a common progenitor, the neural stem cell (NSC). NSCs are defined as undifferentiated neural cells that are characterized by their high proliferative potential while retaining the capacity for self-renewal and multipotency. Glycoconjugates carrying carbohydrate antigens, including glycoproteins, glycolipids, and proteoglycans, are primarily localized on the plasma-membrane surface of cells and serve as excellent biomarkers at various stages of cellular differentiation. Moreover, they also play important functional roles in determining cell fate such as self-renewal, proliferation, and differentiation. In the present review, we discuss the expression pattern and possible functions of glycoconjugates and carbohydrate antigens in NSCs, with an emphasis on stage-specific embryonic antigen-1, human natural killer antigen-1, polysialic acid-neural cell-adhesion molecule, prominin-1, gp130, chondroitin sulfate proteoglycans, heparan sulfate proteoglycans, cystatin C, galectin-1, glycolipids, and Notch.

The expression and functions of glycoconjugates in neural stem cells. Publishing Authors By Initials

M Yanagisawa,RK Yu,

For similar cells: stem cells research abstracts see: cells: stem cells research

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The expression and functions of glycoconjugates in neural stem cells. Journal Published:

PUBLICATION TYPE: Review

Journal: Glycobiology

VOLUME: 17

Page Numbers: 57R-74R

Journal Abbreviation: Glycobiology

ISSN: 0959-6658

DAY: 16

MONTH: 02

YEAR: 2007

The expression and functions of glycoconjugates in neural stem cells. Information

Number of References: 275

LANGUAGE: eng

NlmUniqueID: 9104124

The expression and functions of glycoconjugates in neural stem cells. Keywords Mesh Terms:

KEYWORDS: Stem Cells

MESH TERMS: metabolism

Chemical & Substance for Abstract: The expression and functions of glycoconjugates in neural stem cells. Information

Substance Name: Chondroitin Sulfates

Registry Number: 9007-28-7

Grant and Affiliation Information for The expression and functions of glycoconjugates in neural stem cells.

AFFILIATION: Institute of Molecular Medicine and Genetics and Institute of Neuroscience, Medical College of Georgia, Augusta, GA 30912, USA.

Country: England

AGENCY: United States NINDS

GRANT: NS26994

ACRONYM: NS

MEDLINETA: Glycobiology

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