The evolutionarily conserved BMP-binding protein Twisted gastrulation promotes BMP signalling.

The evolutionarily conserved BMP-binding protein Twisted gastrulation promotes BMP signalling. Research Abstract Details 

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The evolutionarily conserved BMP-binding protein Twisted gastrulation promotes BMP signalling. Abstract Text:

Dorsal-ventral patterning in vertebrate and Drosophila embryos requires a conserved system of extracellular proteins to generate a positional information gradient. The components involved include bone morphogenetic proteins (BMP/Dpp), a BMP antagonist (Chordin/Short gastrulation; Chd/Sog) and a secreted metalloproteinase (Xolloid/Tolloid) that cleaves Chd/Sog. Here we describe Xenopus Twisted gastrulation (xTsg), another member of this signalling pathway. xTsg is expressed ventrally as part of the BMP-4 synexpression group and encodes a secreted BMP-binding protein that is a BMP signalling agonist. The data suggest a molecular mechanism by which xTsg dislodges latent BMPs bound to Chordin BMP-binding fragments generated by Xolloid cleavage, providing a permissive signal that allows high BMP signalling in the embryo. Drosophila Tsg also binds BMPs and is expressed dorsally, supporting the proposal that the dorsal-ventral axis was inverted in the course of animal evolution.

The evolutionarily conserved BMP-binding protein Twisted gastrulation promotes BMP signalling. Publishing Authors By Initials

For similar animals: chordata: vertebrates: amphibia: anura: pipidae: xenopus research abstracts see: animals: chordata: vertebrates: amphibia: anura: pipidae: xenopus research

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The evolutionarily conserved BMP-binding protein Twisted gastrulation promotes BMP signalling. Journal Published:

PUBLICATION TYPE: Research Support, U.S. Gov't,

Journal: Nature

VOLUME: 405

Page Numbers: 757-63

Journal Abbreviation: Nature

ISSN: 0028-0836

DAY: 15

MONTH: Jun

YEAR: 2000

The evolutionarily conserved BMP-binding protein Twisted gastrulation promotes BMP signalling. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 410462

The evolutionarily conserved BMP-binding protein Twisted gastrulation promotes BMP signalling. Keywords Mesh Terms:

KEYWORDS: Xenopus

MESH TERMS: metabolism

Chemical & Substance for Abstract: The evolutionarily conserved BMP-binding protein Twisted gastrulation promotes BMP signalling. Information

Substance Name: chordin

Registry Number: 93586-27-7

Grant and Affiliation Information for The evolutionarily conserved BMP-binding protein Twisted gastrulation promotes BMP signalling.

AFFILIATION: Howard Hughes Medical Institute and Department of Biological Chemistry, University of California, Los Angeles 90095-1662, USA.

Country: ENGLAND

AGENCY: United States NICHD

GRANT: R37 HD021502-14

ACRONYM: HD

MEDLINETA: Nature

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ACCESSION NUMBER: AW258143

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