The evaluation of recombinant hookworm antigens as vaccines in hamsters (Mesocricetus auratus) challenged with human hookworm, Necator americanus.

The evaluation of recombinant hookworm antigens as vaccines in hamsters (Mesocricetus auratus) challenged with human hookworm, Necator americanus. Research Abstract Details 

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The evaluation of recombinant hookworm antigens as vaccines in hamsters (Mesocricetus auratus) challenged with human hookworm, Necator americanus. Abstract Text:

Shuhua Xiao,Bin Zhan,Jian Xue,Gaddam Narsa Goud,Alex Loukas,Yueyuan Liu,Angela Williamson,Sen Liu,Vehid Deumic,Peter Hotez,

We have previously reported the successful adaptation of human hookworm Necator americanus in the golden hamster, Mesocricetus auratus. This animal model was used to test a battery of hookworm (N. americanus and Ancylostoma caninum) recombinant antigens as potential vaccine antigens. Hamsters immunized a leading vaccine candidate N. americanus-Ancylostoma secreted protein 2 (Na-ASP-2) and challenged with N. americanus infective larvae (L3), resulted in 30-46.2% worm reduction over the course of three vaccine trials, relative to adjuvant controls. In addition, significant reduction of worm burdens was also observed in the hamsters immunized with adult hookworm antigens A. caninum aspartic protease 1 (Ac-APR-1); A. caninum-glutathione-S transferase 1 (Ac-GST-1) and Necator cysteine proteases 2 (Na-CP-2) (44.4%, 50.6%, and 29.3%, respectively). Our data on the worm burden reductions afforded by these hookworm antigens approximate the level of protection reported previously from dogs challenged with A. caninum L3, and provide additional evidence to support these hookworm antigens as vaccine candidates for human hookworm infection. The hamster model of N. americanus provides useful information for the selection of antigens to be tested in downstream vaccine development.

The evaluation of recombinant hookworm antigens as vaccines in hamsters (Mesocricetus auratus) challenged with human hookworm, Necator americanus. Publishing Authors By Initials

S Xiao,B Zhan,J Xue,GN Goud,A Loukas,Y Liu,A Williamson,S Liu,V Deumic,P Hotez,

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The evaluation of recombinant hookworm antigens as vaccines in hamsters (Mesocricetus auratus) challenged with human hookworm, Necator americanus. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Experimental parasitology

VOLUME: 118

Page Numbers: 32-40

Journal Abbreviation: Exp. Parasitol.

ISSN: 0014-4894

DAY: 6

MONTH: 06

YEAR: 2007

The evaluation of recombinant hookworm antigens as vaccines in hamsters (Mesocricetus auratus) challenged with human hookworm, Necator americanus. Information

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LANGUAGE: eng

NlmUniqueID: 370713

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Grant and Affiliation Information for The evaluation of recombinant hookworm antigens as vaccines in hamsters (Mesocricetus auratus) challenged with human hookworm, Necator americanus.

AFFILIATION: Institute of Parasitic Diseases, Chinese Center for Disease Control and Prevention, Shanghai 200025, China.

Country: United States

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MEDLINETA: Exp Parasitol

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