The epithelium as a target for therapy in cystic fibrosis.

The epithelium as a target for therapy in cystic fibrosis. Research Abstract Details 

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The epithelium as a target for therapy in cystic fibrosis. Abstract Text:

William R Thelin,Richard C Boucher,

Cystic fibrosis (CF) is characterized by a solute transport defect in epithelial tissues. In the lungs, this defect culminates in the dehydration of the airway surface and mucus accumulation, ultimately leading to chronic bacterial infection. To date, the current therapeutic approaches used to treat CF primarily focus on the secondary manifestations of the disease (e.g. bacterial infection, viscous mucus). However, new therapeutic approaches are targeting the underlying ion transport defect in cystic fibrosis, with the aim of restoring the function of the cystic fibrosis transmembrane conductance regulator, stimulating alternative chloride channels, inhibiting sodium absorption, and utilizing hyperosmotic agents to rehydrate the airway surface. Although still in the development phase, these approaches, used by themselves or in combination, show great promise in the treatment of CF.

The epithelium as a target for therapy in cystic fibrosis. Publishing Authors By Initials

WR Thelin,RC Boucher,

For similar chemical actions and uses: pharmacologic actions: molecular mechanisms of pharmacological action: membrane transport modulators: sodium channel blockers research abstracts see: chemical actions and uses: pharmacologic actions: molecular mechanisms of pharmacological action: membrane transport modulators: sodium channel blockers research

PUBMED ID PMID:

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The epithelium as a target for therapy in cystic fibrosis. Journal Published:

PUBLICATION TYPE: Review

Journal: Current opinion in pharmacology

VOLUME: 7

Page Numbers: 290-5

Journal Abbreviation:

ISSN: 1471-4892

DAY: 1

MONTH: 05

YEAR: 2007

The epithelium as a target for therapy in cystic fibrosis. Information

Number of References: 53

LANGUAGE: eng

NlmUniqueID: 100966133

The epithelium as a target for therapy in cystic fibrosis. Keywords Mesh Terms:

KEYWORDS: Sodium Channel Blockers

MESH TERMS: therapeutic use

Chemical & Substance for Abstract: The epithelium as a target for therapy in cystic fibrosis. Information

Substance Name: Cystic Fibrosis Transmembrane Conductanc

Registry Number: 126880-72-6

Grant and Affiliation Information for The epithelium as a target for therapy in cystic fibrosis.

AFFILIATION: Cystic Fibrosis/Pulmonary Research and Treatment Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.

Country: England

AGENCY: United States NHLBI

GRANT: HL84934

ACRONYM: HL

MEDLINETA: Curr Opin Pharmacol

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