The Enteropathogenic E. coli Effector EspB Facilitates Microvillus Effacing and Antiphagocytosis by Inhibiting Myosin Function.

The Enteropathogenic E. coli Effector EspB Facilitates Microvillus Effacing and Antiphagocytosis by Inhibiting Myosin Function. Research Abstract Details 

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The Enteropathogenic E. coli Effector EspB Facilitates Microvillus Effacing and Antiphagocytosis by Inhibiting Myosin Function. Abstract Text:

Yosuke Iizumi,Hiroshi Sagara,Yasuaki Kabe,Motoki Azuma,Kanako Kume,Michinaga Ogawa,Takeshi Nagai,Peter G Gillespie,Chihiro Sasakawa,Hiroshi Handa,Yosuke Iizumi,Hiroshi Sagara,Yasuaki Kabe,Motoki Azuma,Kanako Kume,Michinaga Ogawa,Takeshi Nagai,Peter G Gillespie,Chihiro Sasakawa,Hiroshi Handa,Yosuke Iizumi,Hiroshi Sagara,Yasuaki Kabe,Motoki Azuma,Kanako Kume,Michinaga Ogawa,Takeshi Nagai,Peter G Gillespie,Chihiro Sasakawa,Hiroshi Handa,

Enteropathogenic Escherichia coli (EPEC) destroys intestinal microvilli and suppresses phagocytosis by injecting effectors into infected cells through a type III secretion system (TTSS). EspB, a component of the TTSS, is also injected into the cytoplasm of host cells. However, the physiological functions of EspB within the host cell cytoplasm remain unclear. We show that EspB binds to myosins, which are a superfamily of proteins that interact with actin filaments and mediate essential cellular processes, including microvillus formation and phagocytosis. EspB inhibits the interaction of myosins with actin, and an EspB mutant that lacks the myosin-binding region maintained its TTSS function but could not induce microvillus effacing or suppress phagocytosis. Moreover, the myosin-binding region of EspB is essential for Citrobacter rodentium, an EPEC-related murine pathogen, to efficiently infect mice. These results suggest that EspB inhibits myosin functions and thereby facilitates efficient infection by EPEC.

The Enteropathogenic E. coli Effector EspB Facilitates Microvillus Effacing and Antiphagocytosis by Inhibiting Myosin Function. Publishing Authors By Initials

Y Iizumi,H Sagara,Y Kabe,M Azuma,K Kume,M Ogawa,T Nagai,PG Gillespie,C Sasakawa,H Handa,Y Iizumi,H Sagara,Y Kabe,M Azuma,K Kume,M Ogawa,T Nagai,PG Gillespie,C Sasakawa,H Handa,Y Iizumi,H Sagara,Y Kabe,M Azuma,K Kume,M Ogawa,T Nagai,PG Gillespie,C Sasakawa,H Handa,

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The Enteropathogenic E. coli Effector EspB Facilitates Microvillus Effacing and Antiphagocytosis by Inhibiting Myosin Function. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Cell host & microbe

VOLUME: 2

Page Numbers: 383-92

Journal Abbreviation: Cell Host Microbe

ISSN: 1934-6069

DAY: 13

MONTH: Dec

YEAR: 2007

The Enteropathogenic E. coli Effector EspB Facilitates Microvillus Effacing and Antiphagocytosis by Inhibiting Myosin Function. Information

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LANGUAGE: eng

NlmUniqueID: 101302316

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Grant and Affiliation Information for The Enteropathogenic E. coli Effector EspB Facilitates Microvillus Effacing and Antiphagocytosis by Inhibiting Myosin Function.

AFFILIATION: Graduate School of Bioscience and Biotechnology, Tokyo Institute of Technology, 4259 Nagatsuta-cho, Midori-ku, Yokohama 226-8501, Japan.

Country: United States

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MEDLINETA: Cell Host Microbe

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