The emerging functions of endocannabinoid signaling during CNS development.

The emerging functions of endocannabinoid signaling during CNS development. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

The emerging functions of endocannabinoid signaling during CNS development. Abstract Text:

Tibor Harkany,Manuel ,Ismael Galve-Roperh,Paul Berghuis,Lakshmi A Devi,Ken Mackie,

In the postnatal brain, endocannabinoids acting as retrograde messengers regulate the function of many synapses. By contrast, the understanding of endocannabinoid functions that regulate fundamental developmental processes such as cell proliferation, migration, differentiation and survival during patterning of the CNS is just beginning to unfold. Increasing the knowledge of basic developmental and signaling principles that are controlled by endocannabinoids will provide important insights into the molecular mechanisms that establish functional neuronal circuits in the brain. Moreover, determining the molecular basis of permanent modifications to cellular structure and intercellular communication imposed by cannabis smoking during pregnancy will provide novel therapeutic targets for alleviating pathogenic changes in affected offspring. Here, we summarize recent findings regarding the ontogeny of the endocannabinoid system in neurons that sculpt the temporal and spatial diversity of cellular functions during CNS development.

The emerging functions of endocannabinoid signaling during CNS development. Publishing Authors By Initials

T Harkany,M ,I Galve-Roperh,P Berghuis,LA Devi,K Mackie,

For similar cells: stem cells research abstracts see: cells: stem cells research

PUBMED ID PMID:

MEDLINE DATE:

The emerging functions of endocannabinoid signaling during CNS development. Journal Published:

PUBLICATION TYPE: Review

Journal: Trends in pharmacological sciences

VOLUME: 28

Page Numbers: 83-92

Journal Abbreviation: Trends Pharmacol. Sci.

ISSN: 0165-6147

DAY: 10

MONTH: 01

YEAR: 2007

The emerging functions of endocannabinoid signaling during CNS development. Information

Number of References: 71

LANGUAGE: eng

NlmUniqueID: 7906158

The emerging functions of endocannabinoid signaling during CNS development. Keywords Mesh Terms:

KEYWORDS: Stem Cells

MESH TERMS: physiology

Chemical & Substance for Abstract: The emerging functions of endocannabinoid signaling during CNS development. Information

Substance Name: Receptors, Cannabinoid

Registry Number: 0

Grant and Affiliation Information for The emerging functions of endocannabinoid signaling during CNS development.

AFFILIATION: Division of Molecular Neurobiology, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm SE-17177, Sweden. tibor.harkany@ki.se

Country: England

AGENCY: United States NINDS

GRANT: NS26880

ACRONYM: NS

MEDLINETA: Trends Pharmacol Sci

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

The emerging functions of endocannabinoid signaling during CNS development Related Publications

• A NEW SLIT-LAMP.
• Adjustment of the School Program for the Physically Handicapped Child.
• Adjustment of the school program for the physically handicapped child.
• Automatic registration of megavoltage to kilovoltage CT images in helical tomotherapy: an evaluation of the setup verification process for the special case of a rigid head phantom.
• Can emotions be truly group level? Evidence regarding four conceptual criteria.
• Comment on "The Southern Ocean biological response to aeolian iron deposition".
• Diagnosis and management of toothwear in two children in the same family: a case report.
• Electromagnetic optimization of multilevel diffractive elements by use of the wavelet transform.
• First do no harm.
• Hypertrophy and physiological death of equine chondrocytes in vitro.
• Immunostaining of peripheral nerves and other tissues in whole mount preparations from hatchling cephalopods.
• Implicit theories about groups and stereotyping: the role of group entitativity.
• Metabotropic suppression of excitation in murine autaptic hippocampal neurons.
• Novel rumen bacterial diversity in two geographically separated sub-species of reindeer.
• Parasitic infections of the lung.
• Personality-targeted interventions delay the growth of adolescent drinking and binge drinking.
• Physiologically based approaches towards the prediction of pharmacokinetics: in vitro-in vivo extrapolation.
• Predicting oral clearance in humans : how close can we get with allometry?
• Radiobiological and treatment planning study of a simultaneously integrated boost for canine nasal tumors using helical tomotherapy.
• Rapid CB(1) cannabinoid receptor desensitization defines the time course of ERK1/2 MAP kinase signaling.
• Report of a symposium on modern methods of preservation of medicinal substances and pharmaceutical preparations.
• Ribotyping of AdherentLactobacillusfrom Weaning Pigs: a Basis for Probiotic Selection Based on Diet and Gut Compartment.
• Stereotypes: static abstractions or dynamic knowledge structures?
• The BaeSR two-component regulatory system mediates resistance to condensed tannins in Escherichia coli.
• The emerging functions of endocannabinoid signaling during CNS development.
• The impact of linac output variations on dose distributions in helical tomotherapy.
• Thinking straight while seeing red: the influence of anger on information processing.
• Ulcerative colitis; a medical and surgical problem.
• Understanding cannabinoid psychoactivity with mouse genetic models.
• When is public health really going to influence service quality?