The efficiency of muscle-derived cell-mediated bone formation.

The efficiency of muscle-derived cell-mediated bone formation. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

The efficiency of muscle-derived cell-mediated bone formation. Abstract Text:

P Bosch,D Musgrave,S Ghivizzani,C Latterman,C S Day,J Huard,

The development of new clinically applicable methods for the delivery of bone morphogenic protein (BMP) is an area of intensive research. Cell-mediated gene therapy approaches are being explored as a potential delivery vehicle. Primary muscle-derived cells isolated from an adult mouse were transduced with an adenoviral-BMP-2 construct. These cells were injected into the triceps surae of severe combined immune deficient (SCID) mice where they induced heterotopic bone formation. BMP-2 expression by these muscle-derived cell constructs was measured in vitro to estimate in vivo BMP-2 delivery. In vitro expression of BMP-2 by 3 x l0(5) muscle-derived cells was 87.89 ng/72 h. These results suggest that the efficiency of muscle cell-based gene delivery of BMP-2 exceeds the direct delivery of recombinant BMP-2 protein.

The efficiency of muscle-derived cell-mediated bone formation. Publishing Authors By Initials

P Bosch,D Musgrave,S Ghivizzani,C Latterman,CS Day,J Huard,

For similar peptides: intercellular signaling peptides and proteins: cytokines: transforming growth factor beta research abstracts see: peptides: intercellular signaling peptides and proteins: cytokines: transforming growth factor beta research

PUBMED ID PMID:

MEDLINE DATE: 2000 Jul-Aug

The efficiency of muscle-derived cell-mediated bone formation. Journal Published:

PUBLICATION TYPE: Research Support, U.S. Gov't,

Journal: Cell transplantation

VOLUME: 9

Page Numbers: 463-70

Journal Abbreviation:

ISSN: 0963-6897

DAY: 19

MONTH: 11

YEAR: 2007

The efficiency of muscle-derived cell-mediated bone formation. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 9208854

The efficiency of muscle-derived cell-mediated bone formation. Keywords Mesh Terms:

KEYWORDS: Transforming Growth Factor beta

MESH TERMS: metabolism

Chemical & Substance for Abstract: The efficiency of muscle-derived cell-mediated bone formation. Information

Substance Name: recombinant human bone morphogenetic pro

Registry Number: 0

Grant and Affiliation Information for The efficiency of muscle-derived cell-mediated bone formation.

AFFILIATION: Department of Orthopaedic Surgery, University of Pittsburgh, PA 15213, USA.

Country: UNITED STATES

AGENCY: United States NIAMS

GRANT: 1P60 AR44811-01

ACRONYM: AR

MEDLINETA: Cell Transplant

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

The efficiency of muscle-derived cell-mediated bone formation Related Publications

• A relationship between vascular endothelial growth factor, angiogenesis, and cardiac repair after muscle stem cell transplantation into ischemic hearts.
• A role for cell sex in stem cell-mediated skeletal muscle regeneration: female cells have higher muscle regeneration efficiency.
• Adenovirus-mediated direct gene therapy with bone morphogenetic protein-2 produces bone.
• Clonal isolation of muscle-derived cells capable of enhancing muscle regeneration and bone healing.
• Decorin gene transfer promotes muscle cell differentiation and muscle regeneration.
• Dominant negative Bmp5 mutation reveals key role of BMPs in skeletal response to mechanical stimulation.
• Effect of bone morphogenetic protein-2-expressing muscle-derived cells on healing of critical-sized bone defects in mice.
• Enhancement of bone healing based on ex vivo gene therapy using human muscle-derived cells expressing bone morphogenetic protein 2.
• Ex vivo gene therapy to produce bone using different cell types.
• Growth factors improve muscle healing in vivo.
• Human skeletal muscle cells in ex vivo gene therapy to deliver bone morphogenetic protein-2.
• Interaction between macrophages, TGF-beta1, and the COX-2 pathway during the inflammatory phase of skeletal muscle healing after injury.
• Malignant transformation of multipotent muscle-derived cells by concurrent differentiation signals.
• Muscle-based gene therapy and tissue engineering.
• Muscle-derived stem cells for tissue engineering and regenerative therapy.
• Osteogenic potential of postnatal skeletal muscle-derived stem cells is influenced by donor sex.
• Osteoprogenitor cells within skeletal muscle.
• Regenerative Medicine for the Musculoskeletal System Based on Muscle-derived Stem Cells.
• Regenerative medicine in orthopaedic surgery.
• Report of case of Löffler's syndrome with a concomitant nonspecific maculo-papular rash.
• Sex differences in muscle-derived stem cells and skeletal muscle.
• Skeletal muscle fiber type conversion during the repair of mouse soleus: potential implications for muscle healing after injury.
• The effect of bone morphogenetic protein-2 expression on the early fate of skeletal muscle-derived cells.
• The efficiency of muscle-derived cell-mediated bone formation.
• [Cellular therapy can be affected by the sex of the stem cell used]
• [Not Available.]
• [Not Available.]
• [Not Available.]
• [Not Available.]
• [Not Available.]