The effects of permeation enhancers on the surface morphology of the rat nasal mucosa: a scanning electron microscopy study.

The effects of permeation enhancers on the surface morphology of the rat nasal mucosa: a scanning electron microscopy study. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

The effects of permeation enhancers on the surface morphology of the rat nasal mucosa: a scanning electron microscopy study. Abstract Text:

R D Ennis,L Borden,W A Lee,

A rat model has been developed to compare relative morphological changes in the nasal mucosa after exposure to potential membrane permeation enhancers. Scanning electron microscopy was used to characterize gross structural and specific cellular changes following exposure. Micrographs of the rat nasal mucosa were scored in four categories: (1) mucosal surface integrity, (2) ciliary morphology, (3) mucus/extracellular debris, and (4) presence of red blood cells. The order of increasing morphological damage resulting from a 5-min exposure to each surfactant was 0.5% Solulan C-24 congruent to 0.5% Solulan C-24/0.5% sodium tauro-24,25-dihydrofusidate (STDHF) less than 0.5% STDHF less than 1.0% STDHF much less than 1.0% Laureth-9 less than 1.0% sodium taurodeoxycholate congruent to 1.0% sodium deoxycholate. The changes observed in the mucosal morphology after exposure to the various surfactants are in general agreement with data in the literature. This model is able to compare rapidly the relative morphological effects on the mucosal membrane of different nasal formulations.

The effects of permeation enhancers on the surface morphology of the rat nasal mucosa: a scanning electron microscopy study. Publishing Authors By Initials

RD Ennis,L Borden,WA Lee,

For similar natural sciences: time: time factors research abstracts see: natural sciences: time: time factors research

PUBMED ID PMID:

MEDLINE DATE:

The effects of permeation enhancers on the surface morphology of the rat nasal mucosa: a scanning electron microscopy study. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Pharmaceutical research

VOLUME: 7

Page Numbers: 468-75

Journal Abbreviation: Pharm. Res.

ISSN: 0724-8741

DAY: 22

MONTH: May

YEAR: 1990

The effects of permeation enhancers on the surface morphology of the rat nasal mucosa: a scanning electron microscopy study. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 8406521

The effects of permeation enhancers on the surface morphology of the rat nasal mucosa: a scanning electron microscopy study. Keywords Mesh Terms:

KEYWORDS: Time Factors

MESH TERMS: pharmacology

Chemical & Substance for Abstract: The effects of permeation enhancers on the surface morphology of the rat nasal mucosa: a scanning electron microscopy study. Information

Substance Name: Fusidic Acid

Registry Number: 6990-06-3

Grant and Affiliation Information for The effects of permeation enhancers on the surface morphology of the rat nasal mucosa: a scanning electron microscopy study.

AFFILIATION: Drug Delivery Department, California Biotechnology Inc., Mountain View 94043.

Country: UNITED STATES

AGENCY:

GRANT:

ACRONYM:

MEDLINETA: Pharm Res

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

The effects of permeation enhancers on the surface morphology of the rat nasal mucosa: a scanning electron microscopy study Related Publications

• A differential response of two putative mammalian circadian regulators, mper1 and mper2, to light.
• Actual Conditions and Countermeasure of Yun-bian Old Men's Health.
• Aspirin changes the secretion rate and amino acid composition of human small intestinal mucin in subjects with ileal conduits.
• Bone morphogenetic protein-2 facilitates expression of chondrogenic, not osteogenic, phenotype of human intervertebral disc cells.
• Channel architecture in maltoporin: dominance studies with lamB mutations influencing maltodextrin binding provide evidence for independent selectivity filters in each subunit.
• Compensation. Costly to a fault.
• Design and feasibility of quick EXAFS scans for a 'broomstick' double-crystal monochromator at PLS beamline.
• Directed evolution of the lambda receptor of Escherichia coli through affinity chromatographic selection.
• Effects of dietary vitamin E supplementation on lipid oxidation and volatiles content of irradiated, cooked turkey meat patties with different packaging.
• Exclusion of high-molecular-weight maltosaccharides by lipopolysaccharide O-antigen of Escherichia coli and Salmonella typhimurium.
• Family decision making for elderly patients in the intensive care unit.
• Identification of an osteogenic protein-1 responsive element in the aggrecan promoter.
• Impairment of conjunctival glutathione secretion and ion transport by oxidative stress in an adenovirus type 5 ocular infection model of pigmented rabbits.
• Inactivation of the PTEN gene protein product is associated with the invasiveness and metastasis, but not angiogenesis, of breast cancer.
• Isolation, by affinity chromatography, of mutant escherichia coli cells with novel regulation of lamB expression.
• Longitudinal clivus fracture associated with trapped basilar artery: unusual survival with good neurological recovery.
• MPer1 and mper2 are essential for normal resetting of the circadian clock.
• Model construction on quality of family caregiving in the elderly.
• Nonredundant roles of the mPer1 and mPer2 genes in the mammalian circadian clock.
• Photoionization studies of sulfur radicals and products of their reactions.
• Posterior transarticular screw fixation for chronic atlanto-axial instability.
• Reciprocal regulation of haem biosynthesis and the circadian clock in mammals.
• Restoration of a loose implant supported crown: a case report.
• Significance of chronic epilepsy in glial tumors and correlation with surgical strategies.
• The circadian gene Period2 plays an important role in tumor suppression and DNA damage response in vivo.
• The effects of permeation enhancers on the surface morphology of the rat nasal mucosa: a scanning electron microscopy study.
• The influence of maltoporin affinity on the transport of maltose and maltohexaose into Escherichia coli.
• Tissue-specific expression, heat inducibility, and biological roles of two hsp16 genes in Caenorhabditis elegans.
• Up-regulation of MUC5AC and MUC5B mucin genes in chronic rhinosinusitis.
• [Expression of MUC3, MUC5AC, MUC6 and epidermal growth factor receptor in gallbladder epithelium according to gallstone composition]