The effects of local administration of Zoledronate solution on the tooth movement and periodontal ligament.

The effects of local administration of Zoledronate solution on the tooth movement and periodontal ligament. Research Abstract Details 

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The effects of local administration of Zoledronate solution on the tooth movement and periodontal ligament. Abstract Text:

Chang Liu,Xinhua Sun,Yuanping Chen,Min Hu,Tang Liang,

OBJECTIVE: To investigate the effects of local administration of Zoledronate solution on the tooth movement and periodontal ligament. METHODS: Orthodontic tooth movement of upper first molar was performed in 42 rats with coil spring. Zoledronate solution was injected into the palatal submucosal area adjacent to the left upper first molar in experimental group 3 days prior to the use of the appliance. In control group, same amount of 0.9% NaCl solution was injected into the palatal submucosal area adjacent to the left and right upper first molar. The injection was applied every third day. The application of mesial force lasted 0.3, 7, 14, 21 days respectively. After the rats were sacrificed, the distance of tooth movement was measured. Sections were stained and then observed with microscope. RESULTS: 1. The distance of tooth movement in the experimental group was significantly smaller than that in the control group. 2. The number of osteoclast on the pressure side in the experiment group was significantly smaller than that in the control group through the experimental period, but there was no distinct difference between experimental group and control group (except for 14 days) for the number of odontoclast in interradicular area. 3. The osteoclasts and odontoclasts were the main target cell of Zoledronate in periodontal tissue. CONCLUSIONS: Zoledronate may be a useful agent for anchorage control and reducing the number of osteoclast on pressure side of alveolar bone.

The effects of local administration of Zoledronate solution on the tooth movement and periodontal ligament. Publishing Authors By Initials

C Liu,X Sun,Y Chen,M Hu,T Liang,

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The effects of local administration of Zoledronate solution on the tooth movement and periodontal ligament. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Zhonghua kou qiang yi xue za zhi = Zhonghua kouqia

VOLUME: 37

Page Numbers: 290-3

Journal Abbreviation: Zhonghua Kou Qiang Yi Xue Za Z

ISSN: 1002-0098

DAY: 4

MONTH: Jul

YEAR: 2002

The effects of local administration of Zoledronate solution on the tooth movement and periodontal ligament. Information

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LANGUAGE: eng

NlmUniqueID: 8711066

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Grant and Affiliation Information for The effects of local administration of Zoledronate solution on the tooth movement and periodontal ligament.

AFFILIATION: Department of Orthodontics, School of Stomatology, Jilin University, Changchun 130041, China.

Country: China

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MEDLINETA: Zhonghua Kou Qiang Yi Xue Za Z

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