[The effects of interleukin-11 on high-dose methotrexate (HDMTX) induced mucositis in Wistar rats.]

[The effects of interleukin-11 on high-dose methotrexate (HDMTX) induced mucositis in Wistar rats.] Research Abstract Details 

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[The effects of interleukin-11 on high-dose methotrexate (HDMTX) induced mucositis in Wistar rats.] Abstract Text:

Yue-qin Han,Li-jun Chen,Xiao-jing Sun,Guo-fa Zhao,Xiu-ying Cheng,

OBJECTIVE: To explore the therapeutic effect of interleukin-11 (IL-11) on high-dose methotrexate (HDMTX) induced mucositis in Wistar's rats, the proliferative effect on CEM leukemia cell line and the antitumor effect on HDMTX. METHODS: Ninety-five 5-week old, 120 - 150 grams weight Wistar rats were randomly divided into five groups. Group A is normal control (n = 15), group B MTX control (n = 20), group C IL-11 pretreatment group before MTX injection (n = 20), group D (n = 20) the high dose IL-11 group (475 microg.kg(-1).d(-1)) after MTX injection, group E (n = 20) the low dose IL-11 group (150 microg.kg(-1).d(-1)) after MTX injection. All rats in group B approximately E were given 1 ml MTX intraperitoneally (100 mg/kg). Rats were killed at day 1, 3, 5, 7 after MTX injection. The mortality rates, changes of small intestine tissue morphology and ultra structure were observed. The proliferation of small intestine crypt cell was assayed by proliferating cell nuclear antigen (PCNA) immunohistochemical staining. MTT method was used to detect the proliferation of CEM cell line. RESULT: IL-11 treatment resulted in a significant increase of survival of HDMTX treated rats, increased of small intestinal villus length and villus/crypt ratio. IL-11 administration was associated with enhancement of small intestine mucosa recovery after HDMTX therapy. Group C showed a greater effect than group B (P < 0.01). IL-11 had no effect on CEM cell proliferation. CONCLUSION: IL-11 has a significant mitigating effect on high-dose MTX induced intestinal mucositis in rat, and significantly increase the survival of the rats. IL-11 could be safely used in the HDMTX treatment of childhood acute lymphocyte leukemia.

[The effects of interleukin-11 on high-dose methotrexate (HDMTX) induced mucositis in Wistar rats.] Publishing Authors By Initials

YQ Han,LJ Chen,XJ Sun,GF Zhao,XY Cheng,

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[The effects of interleukin-11 on high-dose methotrexate (HDMTX) induced mucositis in Wistar rats.] Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Zhonghua xue ye xue za zhi = Zhonghua xueyexue zaz

VOLUME: 25

Page Numbers: 740-4

Journal Abbreviation: Zhonghua Xue Ye Xue Za Zhi

ISSN: 0253-2727

DAY: 25

MONTH: Dec

YEAR: 2004

[The effects of interleukin-11 on high-dose methotrexate (HDMTX) induced mucositis in Wistar rats.] Information

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LANGUAGE: chi

NlmUniqueID: 8212398

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AFFILIATION: Shandong Provincial Hospital, Shandong University, Jinan 252000, China.

Country: China

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MEDLINETA: Zhonghua Xue Ye Xue Za Zhi

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