The effects of centrally administered dexmedetomidine on cardiovascular and sympathetic function in conscious rats.

The effects of centrally administered dexmedetomidine on cardiovascular and sympathetic function in conscious rats. Research Abstract Details 

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The effects of centrally administered dexmedetomidine on cardiovascular and sympathetic function in conscious rats. Abstract Text:

Tetsuro Shirasaka,De-Lai Qiu,Hiroshi Kannan,Mayumi Takasaki,Tetsuro Shirasaka,De-Lai Qiu,Hiroshi Kannan,Mayumi Takasaki,

BACKGROUND: The alpha2-receptor is expressed in the brain, including the hypothalamus, where it is implicated in autonomic nervous system control. The effects of systemic administration of dexmedetomidine (DEX) on cardiovascular responses are well known; however, little is known about the effects of central administration of DEX on cardiovascular responses in conscious animals. In this study, we explored the effects and the mechanism of intracerebroventricularly (icv) administered DEX on cardiovascular responses and sympathetic nerve activity in conscious, unrestrained rats. METHODS: We administered DEX (0.5, 1, and 2 microg/kg) icv and measured the mean arterial blood pressure (MAP), heart rate (HR), and plasma catecholamine in conscious rats (n = 58). Rats were also administered atropine (n = 8), propranolol (n = 8), or hexamethonium (n = 8) to assess the influence of vagal or sympathetic efferent activity in the DEX-induced responses. Some of the rats underwent carotid sinus and aortic nerve denervation to exclude the effect of the baroreceptor reflex. RESULTS: Intracerebroventricular administration of DEX dose-dependently decreased MAP, HR, and plasma norepinephrine. Large dose of DEX decreased plasma epinephrine. The amplitude of MAP reduction induced by DEX was reduced by hexamethonium or propranolol. The amplitude of HR reduction was reduced by atropine or propranolol. The amplitude of MAP and HR reduction induced by DEX were smaller in hexamethonium-pretreatment rats than in intact ones. The amplitude of MAP and HR reduction induced by DEX were larger in sinus and aortic nerve denervation rats than in intact ones. CONCLUSIONS: These results indicate that icv administration of DEX decreases MAP by sympathetic inhibition and decreases HR by sympathetic inhibition and vagal stimulation.

The effects of centrally administered dexmedetomidine on cardiovascular and sympathetic function in conscious rats. Publishing Authors By Initials

T Shirasaka,DL Qiu,H Kannan,M Takasaki,T Shirasaka,DL Qiu,H Kannan,M Takasaki,

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The effects of centrally administered dexmedetomidine on cardiovascular and sympathetic function in conscious rats. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Anesthesia and analgesia

VOLUME: 105

Page Numbers: 1722-8, table of contents

Journal Abbreviation: Anesth. Analg.

ISSN: 1526-7598

DAY: 28

MONTH: Dec

YEAR: 2007

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LANGUAGE: eng

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AFFILIATION: Department of Anesthesiology, Faculty of Medicine, University of Miyazaki, Miyazaki, Japan. shirasak@med.miyazaki-u.ac.jp

Country: United States

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MEDLINETA: Anesth Analg

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