The effects of aging on the bone inductive activity of recombinant human bone morphogenetic protein-2.

The effects of aging on the bone inductive activity of recombinant human bone morphogenetic protein-2. Research Abstract Details 

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The effects of aging on the bone inductive activity of recombinant human bone morphogenetic protein-2. Abstract Text:

J C Fleet,K Cashman,K Cox,V Rosen,

We examined the effects of gain on the ectopic bone-forming ability of recombinant human BMP-2 (rhBMP-2) in rats and investigated the mechanism by which aging might affect this type of bone. Bone formation induced after 12 days of sc implantation of 5 micrograms rhBMP-2 was reduced as animals aged from 1-16 months. The osteocalcin messenger RNA levels of implants also declined in aging animals. When the implant period was doubled, 16-month-old rats formed amounts of bone equivalent to those in 3-month-old rats. Increasing the dose of rhBMP-2 increased bone formation in older rats. To get a response comparable to that seen in 1-month-old rats given 5 micrograms rhBMP-2 for 12 days, 3-month-old rats required 30 micrograms rhBMP-2, whereas 16-month-old rats required 60 micrograms. Treatment with either GH or 1,25-dihydroxyvitamin D3 during the 12-day implantation period returned the bone formation in 16-month-olds rats to that in 3-month-old rats. These studies show that aging blunts rhBMP-2 inducted bone formation in rats. We speculate that the decreased response may be due in part to a decrease in the number of mesenchymal stem cells present in order rats or to a change in the responsiveness of these target cells to rhBMP-2.

The effects of aging on the bone inductive activity of recombinant human bone morphogenetic protein-2. Publishing Authors By Initials

JC Fleet,K Cashman,K Cox,V Rosen,

For similar peptides: intercellular signaling peptides and proteins: cytokines: transforming growth factor beta research abstracts see: peptides: intercellular signaling peptides and proteins: cytokines: transforming growth factor beta research

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The effects of aging on the bone inductive activity of recombinant human bone morphogenetic protein-2. Journal Published:

PUBLICATION TYPE: Research Support, U.S. Gov't,

Journal: Endocrinology

VOLUME: 137

Page Numbers: 4605-10

Journal Abbreviation: Endocrinology

ISSN: 0013-7227

DAY: 19

MONTH: Nov

YEAR: 1996

The effects of aging on the bone inductive activity of recombinant human bone morphogenetic protein-2. Information

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LANGUAGE: eng

NlmUniqueID: 375040

The effects of aging on the bone inductive activity of recombinant human bone morphogenetic protein-2. Keywords Mesh Terms:

KEYWORDS: Transforming Growth Factor beta

MESH TERMS: drug effects

Chemical & Substance for Abstract: The effects of aging on the bone inductive activity of recombinant human bone morphogenetic protein-2. Information

Substance Name: Growth Hormone

Registry Number: 9002-72-6

Grant and Affiliation Information for The effects of aging on the bone inductive activity of recombinant human bone morphogenetic protein-2.

AFFILIATION: Mineral Bioavailability Laboratory, U.S. Department of Agriculture Human Nutrition Research Center on Aging, Tufts University Boston, Massachusetts 02111, USA.

Country: UNITED STATES

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MEDLINETA: Endocrinology

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