The effect of root surface demineralization on bone morphogenetic protein-2-induced healing of rat periodontal fenestration defects.

The effect of root surface demineralization on bone morphogenetic protein-2-induced healing of rat periodontal fenestration defects. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

The effect of root surface demineralization on bone morphogenetic protein-2-induced healing of rat periodontal fenestration defects. Abstract Text:

G N King,N King,F J Hughes,

The purpose of this study was to investigate the effect of acid conditioning of root surfaces during recombinant human bone morphogenetic protein-2 (rhBMP-2) induced periodontal regeneration in vivo. The buccal aspect of molar roots were denuded of their periodontal ligament through a bony window created in the mandible of 34 Wistar rats under general anesthesia. Three groups of 11 or 12 animals received either 10 microL of 50 g/mL rhBMP-2 in a collagen gel over the surgical defect (BMP) or 10 microL of collagen gel only (COL) or were left untreated (UN). Each of the 3 groups were further subdivided into those that received prior root acid conditioning with 35% phosphoric acid gel and those without acid conditioning. Animals were sacrificed 10 days after surgery and the tissues processed for histological examination. The BMP groups with and without acid conditioning developed significantly more bone over the second molar (3.89+/-0.86% and 7.62+/-0.93%, respectively; mean+/-SE), compared with the respective COL (1.24+/-0.26% and 2.77+/-0.52%) and UN groups (1.34+/-0.35% and 3.69+/-0.37%) (P <0.05). Furthermore, significantly more bone was found in the BMP non-acid conditioned group compared with all other groups (P <0.05). Acid conditioning promoted significantly more ankylosis (50%) compared with non-acid conditioning (6.3%) (P=0.007). New cementum formation was greatest in the BMP acid conditioned group (628.4+/-253.8 microm2) and lowest in the non-acid conditioned UN group (207.6+/-36.4 microm2) (P <0.05). This is the first known report evaluating the effects of root acid conditioning after a single application of rhBMP-2 in vivo. Results suggest that root conditioning agents operating at low pH administered into the periodontal wound impairs early BMP-induced osteogenesis while simultaneously promoting BMP-induced cementogenesis.

The effect of root surface demineralization on bone morphogenetic protein-2-induced healing of rat periodontal fenestration defects. Publishing Authors By Initials

GN King,N King,FJ Hughes,

For similar peptides: intercellular signaling peptides and proteins: cytokines: transforming growth factor beta research abstracts see: peptides: intercellular signaling peptides and proteins: cytokines: transforming growth factor beta research

PUBMED ID PMID:

MEDLINE DATE:

The effect of root surface demineralization on bone morphogenetic protein-2-induced healing of rat periodontal fenestration defects. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Journal of periodontology

VOLUME: 69

Page Numbers: 561-70

Journal Abbreviation: J. Periodontol.

ISSN: 0022-3492

DAY: 19

MONTH: May

YEAR: 1998

The effect of root surface demineralization on bone morphogenetic protein-2-induced healing of rat periodontal fenestration defects. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 8000345

The effect of root surface demineralization on bone morphogenetic protein-2-induced healing of rat periodontal fenestration defects. Keywords Mesh Terms:

KEYWORDS: Transforming Growth Factor beta

MESH TERMS: drug effects

Chemical & Substance for Abstract: The effect of root surface demineralization on bone morphogenetic protein-2-induced healing of rat periodontal fenestration defects. Information

Substance Name: phosphoric acid

Registry Number: 7664-38-2

Grant and Affiliation Information for The effect of root surface demineralization on bone morphogenetic protein-2-induced healing of rat periodontal fenestration defects.

AFFILIATION: Department of Periodontology, St Bartholomew's & the Royal London School of Medicine & Dentistry, University of London, UK.

Country: UNITED STATES

AGENCY:

GRANT:

ACRONYM:

MEDLINETA: J Periodontol

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

The effect of root surface demineralization on bone morphogenetic protein-2-induced healing of rat periodontal fenestration defects Related Publications

• A practical approach to common behavior problems.
• A sequential design to estimate sensitivity and specificity of a diagnostic or screening test.
• Bone morphogenetic protein-2 stimulates cell recruitment and cementogenesis during early wound healing.
• Can nutritional manipulation enhance immune competence in broiler chickens?
• Contagious Equine Metritis: A review.
• Corticotropin Releasing Factor (CRF) activation of NF-kappaB-directed transcription in leukocytes.
• Effect of two delivery systems for recombinant human bone morphogenetic protein-2 on periodontal regeneration in vivo.
• Effects of occlusal loading on ankylosis, bone, and cementum formation during bone morphogenetic protein-2-stimulated periodontal regeneration in vivo.
• Evolutionary relationships of vertebrate NACHT domain-containing proteins.
• Fusidic acid-resistant EF-G perturbs the accumulation of ppGpp.
• Galactosyl transferases of baby hamster kidney (BHK) cells. Characterization of two oligosaccharide products synthesised using bovine asialo submaxillary-gland mucin as acceptor.
• Likelihood-ratio tests for positive selection of human and mouse duplicate genes reveal nonconservative and anomalous properties of widely used methods.
• Low-level otoacoustic emissions may predict susceptibility to noise-induced hearing loss.
• Nautiloid growth rhythms and lunar dynamics (reply).
• Nucleotide substitution at the highly polymorphic K1 locus of human herpesvirus 8 (Kaposi's sarcoma-associated herpesvirus).
• Oxidative killing of intracellular parasites mediated by macrophages.
• Pregnancy rates and embryo survival following transfer of bovine embryos stored at 4 degrees C.
• Preliminary studies on bovine embryo survival following short-term storage at 4 degrees C.
• Recombinant human bone morphogenetic protein-2 promotes wound healing in rat periodontal fenestration defects.
• Relationships between sensation seeking and use of caffeine, alcohol and cigarettes by New Zealand university students.
• Reproductive Biology of the Mare - Basic and applied aspects O.J. Ginther; 405 pages; Published by Equiservices, 4343 Garfoot Road, Cross Plains, WI 53528, U.S.A. Telephone (608) 798-4026. $51.00 in USA and Canada, $54.00 elsewhere.
• Retrospective.
• SARS: An Emerging Global Microbial Threat.
• Sexual behavior and serum concentrations of reproductive hormones in normal stallions.
• Should criteria for drug dependence differ across drugs?
• The effect of postpartum uterine lavage on foal heat pregnancy rate.
• The effect of root surface demineralization on bone morphogenetic protein-2-induced healing of rat periodontal fenestration defects.
• The etiology of vomiting in infancy and childhood.
• Towards an outcomes-based system.
• What the pediatrician should know about the management of ocular injuries.