The effect of phenylephrine and pilocarpine on pupil size and aqueous flare intensity in patients with diabetes mellitus.

The effect of phenylephrine and pilocarpine on pupil size and aqueous flare intensity in patients with diabetes mellitus. Research Abstract Details 

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The effect of phenylephrine and pilocarpine on pupil size and aqueous flare intensity in patients with diabetes mellitus. Abstract Text:

PURPOSE: The aqueous flare intensity and pupillary size were studied before and after instillation of 10% phenylephrine and 4% pilocarpine in eyes with diabetes mellitus (DM). METHODS: Twenty-three patients with DM type I were compared with 30 age-matched controls, and 25 patients with DM type II were compared with 30 age-matched controls. Patients with DM were divided into two groups: 1) with mild-moderate nonproliferative diabetic retinopathy (NPDR), and 2) with advanced diabetic retinopathy (DR) which includes moderate-severe, severe NPDR and proliferative DR. The aqueous flare intensity and the horizontal diameter of the pupil were measured before and 60 minutes after topical instillation of 10% phenylephrine and 60 min after topical administration of 4% pilocarpine. RESULTS: Degree of induced mydriasis after phenylephrine instillation was not significantly different between diabetic groups and controls. Significantly less pronounced miosis was observed after stimulation of cholinergic receptors by pilocarpine in eyes with mild-moderate NPDR with DM type II and in eyes with advanced DR with DM type I and type II when compared to controls (p<0.05). Phenylephrine decreased flare intensity in all groups without a significant difference between groups. Pilocarpine instillation increased flare intensity in all groups as compared to flare intensity before any treatment. Also, a significantly smaller increase in flare intensity in eyes with advanced retinopathy in both DM type I and type II was found when compared to controls (p<0.05). CONCLUSION: Pharmacological response to cholinergic stimulation on pupil size and flare intensity is weaker in advanced stages of DR.

The effect of phenylephrine and pilocarpine on pupil size and aqueous flare intensity in patients with diabetes mellitus. Publishing Authors By Initials

For similar nervous system diseases: neurologic manifestations: pupil disorders research abstracts see: nervous system diseases: neurologic manifestations: pupil disorders research

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The effect of phenylephrine and pilocarpine on pupil size and aqueous flare intensity in patients with diabetes mellitus. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Acta ophthalmologica Scandinavica

VOLUME: 76

Page Numbers: 413-6

Journal Abbreviation: Acta Ophthalmol Scand

ISSN: 1395-3907

DAY: 17

MONTH: Aug

YEAR: 1998

The effect of phenylephrine and pilocarpine on pupil size and aqueous flare intensity in patients with diabetes mellitus. Information

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LANGUAGE: eng

NlmUniqueID: 9507578

The effect of phenylephrine and pilocarpine on pupil size and aqueous flare intensity in patients with diabetes mellitus. Keywords Mesh Terms:

KEYWORDS: Pupil Disorders

MESH TERMS: metabolism

Chemical & Substance for Abstract: The effect of phenylephrine and pilocarpine on pupil size and aqueous flare intensity in patients with diabetes mellitus. Information

Substance Name: Pilocarpine

Registry Number: 92-13-7

Grant and Affiliation Information for The effect of phenylephrine and pilocarpine on pupil size and aqueous flare intensity in patients with diabetes mellitus.

AFFILIATION: St. Erik's Eye Hospital, Karolinska Institute, Stockholm, Sweden.

Country: DENMARK

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MEDLINETA: Acta Ophthalmol Scand

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