The effect of pentoxifylline on existing hypersensitivity in a rat model of neuropathy.

The effect of pentoxifylline on existing hypersensitivity in a rat model of neuropathy. Research Abstract Details 

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The effect of pentoxifylline on existing hypersensitivity in a rat model of neuropathy. Abstract Text:

Jian Liu,Weiyan Li,Juan Zhu,Jing Zhang,Xiaomei Feng,Ren Guan,Jianguo Xu,Jian Liu,Weiyan Li,Juan Zhu,Jing Zhang,Xiaomei Feng,Ren Guan,Jianguo Xu,

BACKGROUND: Using a rat L5 spinal nerve transection model we previously showed that pentoxifylline prevents hyperalgesia through antiinflammation in the prefrontal brain. In this study, we examined efficacy when applied after injury. METHODS: We examined the effect of pentoxifylline on existing mechanical allodynia, observing glial activation and proinflammatory cytokine expression in the lumbar spinal cord, when given 7 days after L5 spinal nerve transection. RESULTS: There was no effect from pentoxifylline on existing hypersensitivity, glial activation, and cytokine expression when applied after L5 spinal nerve transection. CONCLUSION: Pentoxifylline administered intraperitoneally on day 7 postsurgery failed to alleviate existing hypersensitivity, or reduce glial activation and cytokine expression.

The effect of pentoxifylline on existing hypersensitivity in a rat model of neuropathy. Publishing Authors By Initials

J Liu,W Li,J Zhu,J Zhang,X Feng,R Guan,J Xu,J Liu,W Li,J Zhu,J Zhang,X Feng,R Guan,J Xu,

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The effect of pentoxifylline on existing hypersensitivity in a rat model of neuropathy. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Anesthesia and analgesia

VOLUME: 106

Page Numbers: 650-3, table of contents

Journal Abbreviation: Anesth. Analg.

ISSN: 1526-7598

DAY: 29

MONTH: Feb

YEAR: 2008

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LANGUAGE: eng

NlmUniqueID: 1310650

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AFFILIATION: Department of Anaesthesiology, Jinling Hospital, School of Medicine, Nanjing University, Nanjing 210002, People's Republic of China. liuj_7610@msn.com

Country: United States

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MEDLINETA: Anesth Analg

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